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Characterizing and Modeling Bone Formation during Mouse Calvarial Development

Marghoub, Arsalan; Libby, Joseph; Babbs, Christian; Ventikos, Yiannis; Fagan, Michael J.; Moazen, Mehran


Arsalan Marghoub

Joseph Libby

Christian Babbs

Yiannis Ventikos

Michael J. Fagan

Mehran Moazen


© 2019 American Physical Society. The newborn mammalian cranial vault consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Early fusion of these sutures leads to a medical condition known as craniosynostosis. The mechanobiology of normal and craniosynostotic skull growth is not well understood. In a series of previous studies, we characterized and modeled radial expansion of normal and craniosynostotic (Crouzon) mice. Here, we describe a new modeling algorithm to simulate bone formation at the sutures in normal and craniosynostotic mice. Our results demonstrate that our modeling approach is capable of predicting the observed ex vivo pattern of bone formation at the sutures in the aforementioned mice. The same approach can be used to model different calvarial reconstruction in children with craniosynostosis to assist in the management of this complex condition.


Marghoub, A., Libby, J., Babbs, C., Ventikos, Y., Fagan, M. J., & Moazen, M. (2019). Characterizing and Modeling Bone Formation during Mouse Calvarial Development. Physical review letters, 122(4), Article 048103.

Journal Article Type Article
Acceptance Date Jan 18, 2019
Online Publication Date Feb 1, 2019
Publication Date Feb 1, 2019
Deposit Date Mar 22, 2019
Publicly Available Date Oct 27, 2022
Journal Physical Review Letters
Print ISSN 0031-9007
Electronic ISSN 1079-7114
Publisher American Physical Society
Peer Reviewed Peer Reviewed
Volume 122
Issue 4
Article Number 048103
Keywords Polymers & soft matter; Biological physics; Interdisciplinary physics
Public URL
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