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Characterizing and Modeling Bone Formation during Mouse Calvarial Development

Marghoub, Arsalan; Libby, Joseph; Babbs, Christian; Ventikos, Yiannis; Fagan, Michael J.; Moazen, Mehran


Arsalan Marghoub

Joseph Libby

Christian Babbs

Yiannis Ventikos

Mehran Moazen


© 2019 American Physical Society. The newborn mammalian cranial vault consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Early fusion of these sutures leads to a medical condition known as craniosynostosis. The mechanobiology of normal and craniosynostotic skull growth is not well understood. In a series of previous studies, we characterized and modeled radial expansion of normal and craniosynostotic (Crouzon) mice. Here, we describe a new modeling algorithm to simulate bone formation at the sutures in normal and craniosynostotic mice. Our results demonstrate that our modeling approach is capable of predicting the observed ex vivo pattern of bone formation at the sutures in the aforementioned mice. The same approach can be used to model different calvarial reconstruction in children with craniosynostosis to assist in the management of this complex condition.

Journal Article Type Article
Publication Date Feb 1, 2019
Journal Physical Review Letters
Print ISSN 0031-9007
Electronic ISSN 1079-7114
Publisher American Physical Society
Peer Reviewed Peer Reviewed
Volume 122
Issue 4
Article Number 048103
APA6 Citation Marghoub, A., Libby, J., Babbs, C., Ventikos, Y., Fagan, M. J., & Moazen, M. (2019). Characterizing and Modeling Bone Formation during Mouse Calvarial Development. Physical review letters, 122(4),
Keywords Polymers & soft matter; Biological physics; Interdisciplinary physics
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