Characterizing and Modeling Bone Formation during Mouse Calvarial Development

Marghoub, Arsalan; Libby, Joseph; Babbs, Christian; Ventikos, Yiannis; Fagan, Michael J.; Moazen, Mehran

Abstract

© 2019 American Physical Society. The newborn mammalian cranial vault consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Early fusion of these sutures leads to a medical condition known as craniosynostosis. The mechanobiology of normal and craniosynostotic skull growth is not well understood. In a series of previous studies, we characterized and modeled radial expansion of normal and craniosynostotic (Crouzon) mice. Here, we describe a new modeling algorithm to simulate bone formation at the sutures in normal and craniosynostotic mice. Our results demonstrate that our modeling approach is capable of predicting the observed ex vivo pattern of bone formation at the sutures in the aforementioned mice. The same approach can be used to model different calvarial reconstruction in children with craniosynostosis to assist in the management of this complex condition.

Citation

Marghoub, A., Libby, J., Babbs, C., Ventikos, Y., Fagan, M. J., & Moazen, M. (2019). Characterizing and Modeling Bone Formation during Mouse Calvarial Development. Physical review letters, 122(4), Article 048103. https://doi.org/10.1103/PhysRevLett.122.048103

• Journal Article Type: Article
• Acceptance Date: Jan 18, 2019
• Online Publication Date: Feb 1, 2019
• Publication Date: Feb 1, 2019
• Deposit Date: Mar 22, 2019
• Publicly Available Date: Mar 22, 2019
• Journal: Physical Review Letters
• Print ISSN: 0031-9007
• Publisher: American Physical Society
• Peer Reviewed: Peer Reviewed
• Volume: 122
• Issue: 4
• Article Number: 048103
• DOI: https://doi.org/10.1103/PhysRevLett.122.048103
• Keywords: Polymers & soft matter; Biological physics; Interdisciplinary physics
• Public URL: https://hull-repository.worktribe.com/output/1382131
• Publisher URL: https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.122.048103
• Contract Date: Mar 22, 2019