Force–length relation of skeletal muscles: from sarcomeres to myofibril

Hou, M..

doi:10.1007/s10237-018-1057-0

Authors

Dr Ming Hou M.Hou@hull.ac.uk
Lecturer

Abstract

Sarcomeres are building blocks of skeletal muscles. Given force–length relations of sarcomeres serially connected in a myofibril, the myofibril force–length relation can be uniquely determined. Necessary and sufficient conditions are derived for capability of fully lengthening or completely shortening a myofibril under isometric, eccentric or concentric contraction, and for the myofibril force–length relation to be a continuous single-valued function. Intriguing phenomena such as sarcomere force–length hysteresis and myofibril regularity are investigated and their important roles in determining myofibril force–length relations are explored. The theoretical analysis leads to experimentally verifiable predictions on myofibril force–length relations. For illustration, simulated force–length relations of a myofibril portion consisting of a sarcomere pair are presented.

Journal Article Type	Article
Publication Date	2018-12
Journal	Biomechanics and Modeling in Mechanobiology
Print ISSN	1617-7940
Electronic ISSN	1617-7940
Publisher	Springer Verlag
Peer Reviewed	Peer Reviewed
Volume	17
Issue	6
Pages	1797-1810
Institution Citation	Hou, M. (2018). Force–length relation of skeletal muscles: from sarcomeres to myofibril. Biomechanics and Modeling in Mechanobiology, 17(6), 1797-1810. https://doi.org/10.1007/s10237-018-1057-0
DOI	https://doi.org/10.1007/s10237-018-1057-0
Keywords	Force–length relation; Sarcomere inhomogeneity; Myofibril regularity; Hysteretic property
Publisher URL	https://link.springer.com/article/10.1007%2Fs10237-018-1057-0#aboutcontent

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