Chabloz Nicolas
Polyfunctionalised nanoparticles bearing robust gadolinium surface units for high relaxivity performance in MRI
Nicolas, Chabloz; Wenzel, Margot; Perry, Hannah; Yoon, Il-Chul; Molisso, Susannah; Stasiuk, Graeme; Elson, Daniel; Cass, Anthony; Wilton-Ely, James
Authors
Margot Wenzel
Hannah Perry
Il-Chul Yoon
Susannah Molisso
Graeme Stasiuk
Daniel Elson
Anthony Cass
James Wilton-Ely
Abstract
The first example of an octadentate gadolinium unit based on DO3A (hydration number q = 1) with a dithiocarbamate tether has been designed and attached to the surface of gold nanoparticles (around 4.4 nm in diameter). In addition to the superior robustness of this attachment, the restricted rotation of the Gd complex on the nanoparticle surface leads to a dramatic increase in relaxivity (r1) from 4.0 mM‐1 s‐1 in unbound form to 34.3 mM‐1 s‐1 (at 10 MHz, 37 °C) and 22 ± 2 mM‐1s‐1 (at 63.87 MHz, 25 °C) when immobilised on the surface. The ‘one‐pot’ synthetic route provides a straightforward and versatile way of preparing a range of multifunctional gold nanoparticles. The incorporation of additional surface units improving biocompatibility (PEG and thioglucose units) and targeting (folic acid) lead to little detrimental effect on the high relaxivity observed for these non‐toxic multifunctional materials. In addition to the passive targeting attributed to gold nanoparticles, the inclusion of a unit capable of targeting the folate receptors overexpressed by cancer cells, such as HeLa cells, illustrates the potential of these assemblies.
Citation
Nicolas, C., Wenzel, M., Perry, H., Yoon, I., Molisso, S., Stasiuk, G., …Wilton-Ely, J. (in press). Polyfunctionalised nanoparticles bearing robust gadolinium surface units for high relaxivity performance in MRI. Chemistry: a European journal, https://doi.org/10.1002/chem.201901820
Journal Article Type | Article |
---|---|
Acceptance Date | May 22, 2019 |
Online Publication Date | May 24, 2019 |
Deposit Date | May 28, 2019 |
Publicly Available Date | May 25, 2020 |
Journal | Chemistry – A European Journal |
Print ISSN | 0947-6539 |
Electronic ISSN | 1521-3765 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
DOI | https://doi.org/10.1002/chem.201901820 |
Keywords | General Chemistry |
Public URL | https://hull-repository.worktribe.com/output/1856587 |
Publisher URL | https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201901820 |
Files
Article
(2.5 Mb)
PDF
Copyright Statement
©2019 The authors
You might also like
Downloadable Citations
About Repository@Hull
Administrator e-mail: repository@hull.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search