Undiagnosed pancreatic exocrine insufficiency and chronic pancreatitis in functional GI disorder patients with diarrhea or abdominal pain

Wong, J.

Abstract

© 2017 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd Background and Aim: A previous UK study showed that 6.1% of patients with diarrhea-predominant irritable bowel syndrome (IBS-D) had evidence of severe pancreatic exocrine insufficiency (PEI), but these findings need replication. We aimed to identify the prevalence of PEI based on fecal elastase stool testing in consecutive outpatients presenting with chronic unexplained abdominal pain and/or diarrhea and/or IBS-D. Methods: Patients aged over 40 years presenting to hospital outpatient clinics from six sites within Australia with unexplained abdominal pain and/or diarrhea for at least 3 months and/or IBS-D were studied. Patients completed validated questionnaires and donated a stool sample in which elastase concentration was measured by ELISA. A concentration of

Citation

Talley, N., Holtmann, G., Nguyen, Q., Gibson, P., Bampton, P., Veysey, M., Wong, J., Philcox, S., Koloski, N., Bunby, L., & Jones, M. (2017). Undiagnosed pancreatic exocrine insufficiency and chronic pancreatitis in functional GI disorder patients with diarrhea or abdominal pain. Journal of Gastroenterology and Hepatology, 32(11), 1813-1817. https://doi.org/10.1111/jgh.13791

• Journal Article Type: Article
• Acceptance Date: Mar 20, 2017
• Online Publication Date: Oct 10, 2017
• Publication Date: Nov 1, 2017
• Deposit Date: Aug 13, 2019
• Print ISSN: 1440-1746
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 32
• Issue: 11
• Pages: 1813-1817
• DOI: https://doi.org/10.1111/jgh.13791
• Public URL: https://hull-repository.worktribe.com/output/1932524
• Publisher URL: https://onlinelibrary.wiley.com/doi/full/10.1111/jgh.13791