Early lifecycle UV‐exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes

Lucock, Mark; Thota, Rohith; Garg, Manohar; Martin, Charlotte; Jones, Patrice; Furst, John; Yates, Zoe; Jablonski, Nina G.; Chaplin, George; Veysey, Martin; Beckett, Emma

Abstract

Objectives
Within the Developmental Origins of Adult Disease (DOHaD) model, early life environmental exposures can confer a long‐term legacy on human health. This mechanism may be adaptive or maladaptive depending on lifestyle circumstances. This article examines the role of first trimester UV‐exposure on late‐life vitamin D levels, and potentially related adaptive and maladaptive phenotypes (height and osteoporosis respectively).

Methods
Six hundred and forty nine subjects were examined for vitamin D2 and D3 (HPLC) and height (stadiometer). Osteoporosis was assessed with an extensive medical history questionnaire.

Results
Solar irradiance over the first 90 days postconception correlated positively with late‐life vitamin D3 (R2 = .0140; P = .0082; β = .1075), but not vitamin D2 levels. It also correlated positively with female adult height (R2 = .170; P = .0103; β = .1291) and negatively with the occurrence of female osteoporosis (P = .0495). All data were adjusted for age and gender as appropriate (unadjusted data also provided). From a contemporary perspective, vitamin D levels varied significantly according to season of blood sampling as might be predicted (P = .0009).

Conclusions
Increased solar irradiance/UV exposure during the first trimester of pregnancy calibrates adult vitamin D metabolism, which is an important hormone in maintaining calcium balance. This may explain how very early lifecycle UV exposure can influence skeletal development (adult height) and modify risk for the skeletal degenerative disorder osteoporosis. The data demonstrate humans are tuned to the world (exposome) in ways we have not yet fully considered, and which are entrained at the earliest phase of the lifecycle.

Citation

Lucock, M., Thota, R., Garg, M., Martin, C., Jones, P., Furst, J., Yates, Z., Jablonski, N. G., Chaplin, G., Veysey, M., & Beckett, E. (2019). Early lifecycle UV‐exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes. American journal of human biology : the official journal of the Human Biology Council, 31(4), Article e23272. https://doi.org/10.1002/ajhb.23272

• Journal Article Type: Article
• Acceptance Date: May 17, 2019
• Online Publication Date: Jun 11, 2019
• Publication Date: Jul 9, 2019
• Deposit Date: Jun 17, 2019
• Publicly Available Date: Jun 12, 2020
• Journal: American Journal of Human Biology
• Print ISSN: 1042-0533
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 31
• Issue: 4
• Article Number: e23272
• DOI: https://doi.org/10.1002/ajhb.23272
• Keywords: Anatomy; Genetics; Ecology, Evolution, Behavior and Systematics; Anthropology
• Public URL: https://hull-repository.worktribe.com/output/2000188
• Publisher URL: https://onlinelibrary.wiley.com/doi/full/10.1002/ajhb.23272
• Contract Date: Jun 17, 2019