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Age-related deviation of gait from normality in alkaptonuria

Barton, Gabor J.; King, Stephanie L.; Robinson, Mark A.; Hawken, Malcolm B.; Ranganath, Lakshminarayan R.

Authors

Gabor J. Barton

Mark A. Robinson

Malcolm B. Hawken

Lakshminarayan R. Ranganath



Contributors

J. Zschocke
Editor

M. Baumgartner
Editor

E. Morava
Editor

M. Patterson
Editor

S. Rahman
Editor

V. Peters
Editor

Abstract

Alkaptonuria is a rare metabolic disease leading to systemic changes including early and severe arthropathy which affects mobility. For unknown reasons, the onset of degenerative changes is delayed to around 30 years of age when both objective and subjective symptoms develop. In order to complement description of the structural changes in alkaptonuria with measures of movement function, clinical gait analysis was added to the list of assessments in 2013. The aim of this study was to describe the deviation of gait from normality as a function of age in patients with alkaptonuria. Three-dimensional movement of reflective markers attached to joints were captured during walking in 39 patients and 10 controls. Subsequent to processing the data to emphasise the shape of marker trajectories, the mean Movement Deviation Profile was generated for all participants. This single number measure gives the deviation of a patient’s gait from a distributed definition of gait normality. Results showed that gait deviation roughly follows a sigmoid profile with minimal increase of gait deviations in a younger patient group and an abrupt large increase around the second half of the 4th decade of life. Larger variations of gait deviations were found in the older group than in the younger group suggesting a complex interaction of multiple factors which determine gait function after symptoms manifest. Continued gait analysis of adults with AKU, extended to younger adults and children with AKU, is expected to complete understanding of both the natural history of alkaptonuria and how interventions can affect movement function.

Journal Article Type Article
Publication Date 2015
Journal JIMD Reports; JIMD Reports, Volume 24
Print ISSN 2192-8304
Electronic ISSN 2192-8312
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 24
Pages 39-44
ISBN 9783662482261; 9783662482278
APA6 Citation Barton, G. J., King, S. L., Robinson, M. A., Hawken, M. B., & Ranganath, L. R. (2015). Age-related deviation of gait from normality in alkaptonuria. JIMD Reports, 24, 39-44. https://doi.org/10.1007/8904_2015_431
DOI https://doi.org/10.1007/8904_2015_431
Publisher URL https://link.springer.com/chapter/10.1007%2F8904_2015_431
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