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Synthesis, structure, and cytotoxicity studies of oxidovanadium(IV and V) complexes bearing chelating phenolates

Miller-Shakesby, David M.; Nigam, Shubhanchi; Brookfield, Adam; Archibald, Stephen J.; Redshaw, Carl; McInnes, Eric J.L.; Prior, Timothy J.

Authors

David M. Miller-Shakesby

Shubhanchi Nigam

Adam Brookfield

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Professor Carl Redshaw C.Redshaw@hull.ac.uk
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry

Eric J.L. McInnes



Abstract

The interaction of [VO(acac)2] with 2,6-bis(hydroxymethyl)-4-methylphenol (L1H3) or 6,6/-methylenebis(4-tert-butyl-2-(hydroxymethyl)phenol) (L2H4) in refluxing toluene afforded, following work-up in ethanol, the complexes [VOL1]2 (1) and {[VO(acac)(HOEt)](VO)L2]}2 (2), respectively. Use of 4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid (L3H2) or 4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzosulfonic acid (L4H2) with [VOCl3] in refluxing acetonitrile, followed by methanol and THF work-up, afforded the complexes [Et3NH][VO(OMe)L3]2 (3) and [Et3NH][VO(OMe)L4]2 (4), respectively. The interaction of [VOSO4] and L3H2 in refluxing acetonitrile afforded, with extraction into methanol, the complex [VO(OMe)L3]2 (5). The molecular structures of 2, 3 and 5 have been determined; the structure of 1 has been reported previously. The complexes in this study have been determined to be of low toxicity using in vitro cell assays with 50% cytotoxicity values (CC50) values in the range 56 – 126 µM.

Citation

Miller-Shakesby, D. M., Nigam, S., Brookfield, A., McInnes, E. J., Prior, T. J., Archibald, S. J., & Redshaw, C. (2019). Synthesis, structure, and cytotoxicity studies of oxidovanadium(IV and V) complexes bearing chelating phenolates. Polyhedron, 171, 1-9. https://doi.org/10.1016/j.poly.2019.06.051

Journal Article Type Article
Acceptance Date Jun 26, 2019
Online Publication Date Jul 5, 2019
Publication Date Oct 1, 2019
Deposit Date Jul 30, 2019
Publicly Available Date Jul 6, 2020
Journal Polyhedron
Print ISSN 0277-5387
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 171
Pages 1-9
DOI https://doi.org/10.1016/j.poly.2019.06.051
Keywords Vanadium; Phenolates; Chelates, crystal structures; Cytotoxicity
Public URL https://hull-repository.worktribe.com/output/2261340
Publisher URL https://www.sciencedirect.com/science/article/pii/S0277538719304620?via%3Dihub
Additional Information ©2019, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

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