Skip to main content

Research Repository

Advanced Search

Exercise training as a mediator for enhancing coronary collateral circulation: A review of the evidence

Nickolay, Thomas; Nichols, Simon; Ingle, Lee; Hoye, Angela

Authors

Thomas Nickolay

Simon Nichols

Angela Hoye



Abstract

Coronary collateral vessels supply blood to areas of myocardium at risk after arterial occlusion. Flow through these channels is driven by a pressure gradient between the donor and occluded artery. Concomitant with increased collateral flow is an increase in shear force, a potent stimulus for collateral development (arteriogenesis). Arteriogenesis is self-limiting, often ceasing prematurely when the pressure gradient is reduced by the expanding lumen of the collateral vessel. After the collateral has reached its self-limited maximal conductance, the only way to drive further increases is to re-establish the pressure gradient.
During exercise, the myocardial oxygen demand is increased, subsequently increasing coronary flow. Therefore, exercise may represent a means of driving augmenting arteriogenesis in patients with stable coronary artery disease. Studies investigating the ability of exercise to drive collateral development in humans are inconsistent. However, these inconsistencies may be due to the heterogeneity of assessment methods used to quantify change. This article summarises current evidence pertaining to the role of exercise in the development of coronary collaterals, highlighting areas of future research.

Citation

Nickolay, T., Nichols, S., Ingle, L., & Hoye, A. (2019). Exercise training as a mediator for enhancing coronary collateral circulation: A review of the evidence. Current Cardiology Reviews, 15, https://doi.org/10.2174/1573403x15666190819144336

Journal Article Type Article
Acceptance Date Aug 16, 2019
Online Publication Date Aug 19, 2019
Publication Date Aug 19, 2019
Deposit Date Aug 21, 2019
Publicly Available Date Aug 20, 2020
Journal Current Cardiology Reviews
Print ISSN 1573-403X
Publisher Bentham Science Publishers
Peer Reviewed Peer Reviewed
Volume 15
DOI https://doi.org/10.2174/1573403x15666190819144336
Keywords Cardiology and Cardiovascular Medicine; General Medicine
Public URL https://hull-repository.worktribe.com/output/2494402
Publisher URL http://www.eurekaselect.com/174303/article

Files







You might also like



Downloadable Citations