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Combined magnetic resonance imaging and photodynamic therapy using polyfunctionalised nanoparticles bearing robust gadolinium surface units

Chabloz, Nicolas; Perry, Hannah; Yoon, Il-Chul; Coulson, Andrew; White, Andrew; Stasiuk, Graeme; Botnar, Rene; Wilton-Ely, James

Authors

Nicolas Chabloz

Hannah Perry

Il-Chul Yoon

Andrew Coulson

Andrew White

Graeme Stasiuk

Rene Botnar

James Wilton-Ely



Abstract

A robust dithiocarbamate tether allows novel gadolinium units based on DOTAGA (q = 1) to be attached to the surface of gold nanoparticles (2.6 ‐ 4.1 nm diameter) along with functional units offering biocompatibility, targeting and photodynamic therapy. A dramatic increase in relaxivity (r1) per Gd unit from 5.01 mM−1 s−1 in unbound form to 31.68 mM−1 s−1 (10 MHz, 37 °C) is observed when immobilised on the surface due to restricted rotation and enhanced rigidity of the Gd complex on the nanoparticle surface. The single‐step synthetic route provides a straightforward and versatile way of preparing multifunctional gold nanoparticles, including examples with conjugated zinc‐tetraphenylporphyrin photosensitizers. The lack of toxicity of these materials (MTT assays) is transformed on irradiation of HeLa cells for 30 minutes (PDT), leading to 75% cell death. In addition to passive targeting, the inclusion of units capable of actively targeting overexpressed folate receptors illustrates the potential of these assemblies as targeted theranostic agents.

Journal Article Type Article
Journal Chemistry – A European Journal
Print ISSN 0947-6539
Electronic ISSN 1521-3765
Publisher Wiley
Peer Reviewed Peer Reviewed
APA6 Citation Chabloz, N., Perry, H., Yoon, I., Coulson, A., White, A., Stasiuk, G., …Wilton-Ely, J. (in press). Combined magnetic resonance imaging and photodynamic therapy using polyfunctionalised nanoparticles bearing robust gadolinium surface units. Chemistry : a European journal, https://doi.org/10.1002/chem.201904757
DOI https://doi.org/10.1002/chem.201904757
Keywords General chemistry; gadolinium; imaging agents; MRI; Nanoparticles; PDT
Additional Information Received: 2019-10-18; Accepted: 2020-01-23; Published: 2020-01-25
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