Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds

Wilkinson, Holly N.; Hardman, Matthew J.

doi:10.3389/fcell.2020.00773

Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds

Wilkinson, Holly N.; Hardman, Matthew J.

Authors

Dr Holly Wilkinson H.N.Wilkinson@hull.ac.uk
Lecturer in Wound Healing

Professor Matthew Hardman M.Hardman@hull.ac.uk
Chair in Wound Healing / HYMS Director of Research

Abstract

© Copyright © 2020 Wilkinson and Hardman. Cellular senescence is a fundamental stress response that restrains tumour formation. Yet, senescence cells are also present in non-cancerous states, accumulating exponentially with chronological age and contributing to age- and diabetes-related cellular dysfunction. The identification of hypersecretory and phagocytic behaviours in cells that were once believed to be non-functional has led to a recent explosion of senescence research. Here we discuss the profound, and often opposing, roles identified for short-lived vs. chronic tissue senescence. Transiently induced senescence is required for development, regeneration and acute wound repair, while chronic senescence is widely implicated in tissue pathology. We recently demonstrated that sustained senescence contributes to impaired diabetic healing via the CXCR2 receptor, which when blocked promotes repair. Further studies have highlighted the beneficial effects of targeting a range of senescence-linked processes to fight disease. Collectively, these findings hold promise for developing clinically viable strategies to tackle senescence in chronic wounds and other cutaneous pathologies.

Citation

Wilkinson, H. N., & Hardman, M. J. (2020). Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds. Frontiers in Cell and Developmental Biology, 8, Article 773. https://doi.org/10.3389/fcell.2020.00773

Journal Article Type	Article
Acceptance Date	Jul 22, 2020
Online Publication Date	Aug 11, 2020
Publication Date	Aug 11, 2020
Deposit Date	Aug 15, 2020
Publicly Available Date	Aug 17, 2020
Journal	Frontiers in Cell and Developmental Biology
Electronic ISSN	2296-634X
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	8
Article Number	773
DOI	https://doi.org/10.3389/fcell.2020.00773
Keywords	Senescence; Ageing; Diabetes; Wound healing; Senolytics
Public URL	https://hull-repository.worktribe.com/output/3558805
Publisher URL	https://www.frontiersin.org/articles/10.3389/fcell.2020.00773/full

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Copyright Statement
© 2020 Wilkinson and Hardman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.