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Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds

Wilkinson, Holly N.; Hardman, Matthew J.

Authors

Holly N. Wilkinson

Matthew J. Hardman



Abstract

© Copyright © 2020 Wilkinson and Hardman. Cellular senescence is a fundamental stress response that restrains tumour formation. Yet, senescence cells are also present in non-cancerous states, accumulating exponentially with chronological age and contributing to age- and diabetes-related cellular dysfunction. The identification of hypersecretory and phagocytic behaviours in cells that were once believed to be non-functional has led to a recent explosion of senescence research. Here we discuss the profound, and often opposing, roles identified for short-lived vs. chronic tissue senescence. Transiently induced senescence is required for development, regeneration and acute wound repair, while chronic senescence is widely implicated in tissue pathology. We recently demonstrated that sustained senescence contributes to impaired diabetic healing via the CXCR2 receptor, which when blocked promotes repair. Further studies have highlighted the beneficial effects of targeting a range of senescence-linked processes to fight disease. Collectively, these findings hold promise for developing clinically viable strategies to tackle senescence in chronic wounds and other cutaneous pathologies.

Journal Article Type Article
Publication Date Aug 11, 2020
Journal Frontiers in Cell and Developmental Biology
Electronic ISSN 2296-634X
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 8
Article Number 773
APA6 Citation Wilkinson, H. N., & Hardman, M. J. (2020). Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds. Frontiers in Cell and Developmental Biology, 8, https://doi.org/10.3389/fcell.2020.00773
DOI https://doi.org/10.3389/fcell.2020.00773
Keywords Senescence; Ageing; Diabetes; Wound healing; Senolytics
Publisher URL https://www.frontiersin.org/articles/10.3389/fcell.2020.00773/full

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Copyright Statement
© 2020 Wilkinson and Hardman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.





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