Adrenomedullin and the microvasculature

Nikitenko, Leonid L.; Smith, David M.; Hague, Stephen; Wilson, Caroline R.; Bicknell, Roy; Rees, Margaret C.P.

Abstract

The peptide adrenomedullin shows a remarkable range of effects on the vasculature that include vasodilatation, regulation of vascular smooth muscle cell proliferation, inhibition of endothelial apoptosis and promotion of angiogenesis. It is becoming clear that either activation or disruption of adrenomedullin signalling might contribute to many pathologies including cardiovascular disease, pulmonary hypertension, atherosclerosis, renal failure, neoplastic growth, inflammatory disease and disorders of the reproductive tract. Recent advances in this area are reviewed.

Citation

Nikitenko, L. L., Smith, D. M., Hague, S., Wilson, C. R., Bicknell, R., & Rees, M. C. (2002). Adrenomedullin and the microvasculature. Trends in Pharmacological Sciences, 23(3), 101-103. https://doi.org/10.1016/S0165-6147%2800%2901983-0

• Journal Article Type: Review
• Publication Date: Mar 1, 2002
• Deposit Date: May 3, 2022
• Journal: Trends in Pharmacological Sciences
• Print ISSN: 0165-6147
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 23
• Issue: 3
• Pages: 101-103
• DOI: https://doi.org/10.1016/S0165-6147%2800%2901983-0
• Public URL: https://hull-repository.worktribe.com/output/3571084