Gender-Specific Differences on the Association of Hypertension with Subclinical Thyroid Dysfunction

Zhang, Jingkai; Huang, Chao; Meng, Zhaowei; Fan, Yaguang; Yang, Qing; Zhang, Wenjuan; Gao, Yuxia; Yang, Zhenwen; Cai, Heng; Bian, Bo; Li, Yongle; Yu, Xuefang; Du, Xin; Xu, Shaopeng; Nie, Jing; Liu, Ming; Sun, Jinhong; Zhang, Qing; Gao, Ying; Song, Kun; Wang, Xing; Zhao, Li

Abstract

© 2019 Jingkai Zhang et al. Objective. Both hypertension and subclinical thyroid dysfunction (STD) have high prevalence and clinical importance, but their relationship is still a matter of debate. We aimed to explore gender-specific difference on the association between hypertension and STD in Chinese. Methods. We recruited 13,380 ostensible healthy participants (8,237 men and 5,143 women). The associations between hypertension and STD were analyzed on a gender-based setting after dividing STD into subclinical hypothyroidism, subclinical hyperthyroidism and further subgrouped euthyroidism. Crude and adjusted odds ratios of STD for hypertension were analyzed by binary logistic regression. Results. An increasing trend of hypertension prevalence was found along with aging in both genders. Yet, higher male hypertension prevalence was found until 65 years, and then it intersected with female hypertension prevalence. Women had significantly higher propensity for STD than men. Yet, in elderly participants, this gender-specific difference became less obvious. We displayed detrimental effects for subclinical hypothyroidism in both genders after multiple-covariate adjustments, yet no such effects were shown for subclinical hyperthyroidism. Moreover, females with subclinical hypothyroidism were more likely to be associated with hypertension than males, and the corresponding odds ratios were 1.619 (P

Citation

Zhang, J., Huang, C., Meng, Z., Fan, Y., Yang, Q., Zhang, W., Gao, Y., Yang, Z., Cai, H., Bian, B., Li, Y., Yu, X., Du, X., Xu, S., Nie, J., Liu, M., Sun, J., Zhang, Q., Gao, Y., Song, K., …Zhao, L. (2019). Gender-Specific Differences on the Association of Hypertension with Subclinical Thyroid Dysfunction. International Journal of Endocrinology, 2019, Article 6053068. https://doi.org/10.1155/2019/6053068

• Journal Article Type: Article
• Acceptance Date: Nov 20, 2019
• Online Publication Date: Dec 30, 2019
• Publication Date: Jan 1, 2019
• Deposit Date: Jun 8, 2022
• Publicly Available Date: Oct 23, 2024
• Journal: International Journal of Endocrinology
• Print ISSN: 1687-8337
• Electronic ISSN: 1687-8345
• Publisher: Hindawi
• Peer Reviewed: Peer Reviewed
• Volume: 2019
• Article Number: 6053068
• DOI: https://doi.org/10.1155/2019/6053068
• Public URL: https://hull-repository.worktribe.com/output/3599346