Abu Saleh Md Moin
Hypoglycaemia in type 2 diabetes exacerbates amyloid-related proteins associated with dementia
Moin, Abu Saleh Md; Al-Qaissi, Ahmed; Sathyapalan, Thozhukat; Atkin, Stephen L.; Butler, Alexandra E.
Stephen L. Atkin
Alexandra E. Butler
Hypoglycemia in diabetes (T2D) may increase the risk for Alzheimer's disease (AD). We hypothesized that hypoglycemia‐induced amyloid‐related protein changes would be exacerbated in T2D.
A prospective, parallel study in T2D (n=23) and controls (n=23). Subjects underwent insulin‐induced hypoglycemia with blood sampling at baseline, hypoglycemia and post‐hypoglycemia; proteomic analysis of amyloid‐related proteins was undertaken.
At baseline: Amyloid‐precursor protein (APP) (p
Moin, A. S. M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (in press). Hypoglycaemia in type 2 diabetes exacerbates amyloid-related proteins associated with dementia. Diabetes, Obesity and Metabolism, https://doi.org/10.1111/dom.14220
|Journal Article Type||Article|
|Acceptance Date||Oct 4, 2020|
|Online Publication Date||Oct 7, 2020|
|Deposit Date||Oct 13, 2020|
|Publicly Available Date||Oct 8, 2021|
|Journal||Diabetes, Obesity and Metabolism|
|Peer Reviewed||Peer Reviewed|
|Keywords||Type 2 diabetes; Hypoglycemia; Dementia; Alzheimer's disease; Amyloid‐related proteins|
|Additional Information||Received: 2020-08-19; Accepted: 2020-10-04; Published: 2020-10-07|
This file is under embargo until Oct 8, 2021 due to copyright reasons.
Contact T.Sathyapalan@hull.ac.uk to request a copy for personal use.
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