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Hypoglycaemia in type 2 diabetes exacerbates amyloid-related proteins associated with dementia

Moin, Abu Saleh Md; Al-Qaissi, Ahmed; Sathyapalan, Thozhukat; Atkin, Stephen L.; Butler, Alexandra E.

Authors

Abu Saleh Md Moin

Ahmed Al-Qaissi

Thozhukat Sathyapalan

Stephen L. Atkin

Alexandra E. Butler



Abstract

Objective
Hypoglycemia in diabetes (T2D) may increase the risk for Alzheimer's disease (AD). We hypothesized that hypoglycemia‐induced amyloid‐related protein changes would be exacerbated in T2D.

Methods
A prospective, parallel study in T2D (n=23) and controls (n=23). Subjects underwent insulin‐induced hypoglycemia with blood sampling at baseline, hypoglycemia and post‐hypoglycemia; proteomic analysis of amyloid‐related proteins was undertaken.

Results
At baseline: Amyloid‐precursor protein (APP) (p

Citation

Moin, A. S. M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (in press). Hypoglycaemia in type 2 diabetes exacerbates amyloid-related proteins associated with dementia. Diabetes, Obesity and Metabolism, https://doi.org/10.1111/dom.14220

Journal Article Type Article
Acceptance Date Oct 4, 2020
Online Publication Date Oct 7, 2020
Deposit Date Oct 13, 2020
Publicly Available Date Oct 8, 2021
Journal Diabetes, Obesity and Metabolism
Print ISSN 1462-8902
Electronic ISSN 1463-1326
Publisher Wiley
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1111/dom.14220
Keywords Type 2 diabetes; Hypoglycemia; Dementia; Alzheimer's disease; Amyloid‐related proteins
Public URL https://hull-repository.worktribe.com/output/3633660
Publisher URL https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14220
Additional Information Received: 2020-08-19; Accepted: 2020-10-04; Published: 2020-10-07