Salivary testosterone measurement in women with and without polycystic ovary syndrome
Sathyapalan, Thozhukat; Al-Qaissi, Ahmed; Kilpatrick, Eric S.; Atkin, Stephen; Dargham, Soha R.; Adaway, Joanne; Dargham, Soha; Kilpatrick, Eric; Keevil, Brian; Atkin, Stephen L.
Eric S. Kilpatrick
Soha R. Dargham
Stephen L. Atkin
Clinical and/or biochemical hyperandrogenism is one of the diagnostic criteria for PCOS. An evaluation of the role of salivary testosterone (salT) and androstenedione (salA) for the diagnosis of PCOS was undertaken in a cross sectional study involving 65 women without PCOS and 110 women with PCOS fulfilling all 3 diagnostic Rotterdam criteria. Serum and salivary androgen measurements were determined by LC-MS/MS. salT and salA were significantly elevated in PCOS compared to controls (P<001). No androgen marker was more predictive than another using ROC curves, but multiple logistic regression suggested salT was more predictive than free androgen index (FAI)(p<0.01). The combination of salT or FAI identified 100% of PCOS women. PCOS women with both biochemical and clinical hyperandrogenism as opposed to clinical hyperandrogenism alone showed a metabolic phenotype (p<0.05) and insulin resistance(p<0.001). PCOS patients with an isolated elevated FAI showed increased insulin resistance compared to those with an isolated salT(P<0.05). salT appeared to be at least as predictive as FAI for the diagnosis of the classical PCOS phenotype, and the combination of salT or FAI identified 100% of PCOS patients. This suggests that salT measurement by LC-MS/MS holds the promise of complementing existing laboratory tests as a means of assessing hyperandrogenemia.
Sathyapalan, T., Al-Qaissi, A., Kilpatrick, E. S., Dargham, S. R., Adaway, J., Keevil, B., & Atkin, S. L. (2017). Salivary testosterone measurement in women with and without polycystic ovary syndrome. Scientific reports, 7(1), https://doi.org/10.1038/s41598-017-03945-w
|Journal Article Type||Article|
|Acceptance Date||May 5, 2017|
|Online Publication Date||Jun 15, 2017|
|Publication Date||Dec 1, 2017|
|Deposit Date||May 11, 2017|
|Publicly Available Date||Jun 15, 2017|
|Publisher||Nature Publishing Group|
|Peer Reviewed||Peer Reviewed|
|Article Number||ARTN 3589|
|Keywords||Polycystic ovary syndrome, Testosterone|
|Additional Information||Copy of article first published in: Scientific reports, 2017, v.7|
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