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Salivary testosterone measurement in women with and without polycystic ovary syndrome

Sathyapalan, Thozhukat; Al-Qaissi, Ahmed; Kilpatrick, Eric S.; Atkin, Stephen; Dargham, Soha R.; Adaway, Joanne; Dargham, Soha; Kilpatrick, Eric; Keevil, Brian; Atkin, Stephen L.

Authors

Thozhukat Sathyapalan

Ahmed Al-Qaissi

Eric S. Kilpatrick

Stephen Atkin

Soha R. Dargham

Joanne Adaway

Soha Dargham

Eric Kilpatrick

Brian Keevil

Stephen L. Atkin



Abstract

Clinical and/or biochemical hyperandrogenism is one of the diagnostic criteria for PCOS. An evaluation of the role of salivary testosterone (salT) and androstenedione (salA) for the diagnosis of PCOS was undertaken in a cross sectional study involving 65 women without PCOS and 110 women with PCOS fulfilling all 3 diagnostic Rotterdam criteria. Serum and salivary androgen measurements were determined by LC-MS/MS. salT and salA were significantly elevated in PCOS compared to controls (P<001). No androgen marker was more predictive than another using ROC curves, but multiple logistic regression suggested salT was more predictive than free androgen index (FAI)(p<0.01). The combination of salT or FAI identified 100% of PCOS women. PCOS women with both biochemical and clinical hyperandrogenism as opposed to clinical hyperandrogenism alone showed a metabolic phenotype (p<0.05) and insulin resistance(p<0.001). PCOS patients with an isolated elevated FAI showed increased insulin resistance compared to those with an isolated salT(P<0.05). salT appeared to be at least as predictive as FAI for the diagnosis of the classical PCOS phenotype, and the combination of salT or FAI identified 100% of PCOS patients. This suggests that salT measurement by LC-MS/MS holds the promise of complementing existing laboratory tests as a means of assessing hyperandrogenemia.

Citation

Sathyapalan, T., Al-Qaissi, A., Kilpatrick, E. S., Dargham, S. R., Adaway, J., Keevil, B., & Atkin, S. L. (2017). Salivary testosterone measurement in women with and without polycystic ovary syndrome. Scientific reports, 7(1), https://doi.org/10.1038/s41598-017-03945-w

Journal Article Type Article
Acceptance Date May 5, 2017
Online Publication Date Jun 15, 2017
Publication Date Dec 1, 2017
Deposit Date May 11, 2017
Publicly Available Date Jun 15, 2017
Journal Scientific reports
Print ISSN 2045-2322
Electronic ISSN 2045-2322
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 7
Issue 1
Article Number ARTN 3589
DOI https://doi.org/10.1038/s41598-017-03945-w
Keywords Polycystic ovary syndrome, Testosterone
Public URL https://hull-repository.worktribe.com/output/368776
Publisher URL https://www.nature.com/articles/s41598-017-03945-w
Additional Information Copy of article first published in: Scientific reports, 2017, v.7

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