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Recent advances in drug discovery for diabetic kidney disease

Danta, Chhanda Charan; Boa, Andrew N.; Bhandari, Sunil; Sathyapalan, Thozhukat; Xu, Shang Zhong


Chhanda Charan Danta

Sunil Bhandari


Introduction: Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD), and 40% of patients with diabetes develop DKD. Although some pathophysiological mechanisms and drug targets of DKD have been described, the effectiveness or clinical usefulness of such treatment has not been well validated. Therefore, searching for new targets and potential therapeutic candidates has become an emerging research area. Areas covered: The pathophysiological mechanisms, new drug targets and potential therapeutic compounds for DKD are addressed in this review. Expert opinion: Although preclinical and clinical evidence has shown some positive results for controlling DKD progression, treatment regimens have not been well developed to reduce the mortality in patients with DKD globally. Therefore, the discovery of new therapeutic targets and effective target-based drugs to achieve better and safe treatment are urgently required. Preclinical screening and clinical trials for such drugs are needed.


Danta, C. C., Boa, A. N., Bhandari, S., Sathyapalan, T., & Xu, S. Z. (2021). Recent advances in drug discovery for diabetic kidney disease. Expert Opinion on Drug Discovery, 16(4), 447-461.

Journal Article Type Review
Acceptance Date Sep 30, 2020
Online Publication Date Oct 28, 2020
Publication Date 2021
Deposit Date Dec 16, 2020
Publicly Available Date Oct 29, 2021
Journal Expert Opinion on Drug Discovery
Print ISSN 1746-0441
Electronic ISSN 1746-045X
Publisher Taylor and Francis
Peer Reviewed Peer Reviewed
Volume 16
Issue 4
Pages 447-461
Keywords Diabetic complications; Diabetic nephropathy; Drug discovery; Endothelin receptor blockers; Oxidative stress; Renin-angiotensin-aldosterone system; SGLT-2 inhibitors
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