The Role of Chemokines in Thyroid Carcinoma

Yapa, Sharinie; Mulla, Omar; Green, Victoria; England, James; Greenman, John

Abstract

© Copyright 2017, Mary Ann Liebert, Inc. 2017. The global incidence of thyroid cancer is increasing, and metastatic spread to the lymph nodes is common in papillary thyroid carcinoma. The metastatic course of thyroid carcinoma is an intricate process involving invasion, angiogenesis, cell trafficking, extravasation, organ specific homing, and growth. A key aspect in this process involves a multitude of interactions between chemokines and their receptors. Chemokines are a group of small proteins, which act to elicit normal physiologic and immune responses principally through recruitment of specific cell populations to the site of infection or malignancy. Thyroid cancer cells, like other tumors, possess the ability to corrupt the chemokine system to their advantage by altering cell movement into the tumor microenvironment and affecting all aspects of thyroid cancer progression.

Citation

Yapa, S., Mulla, O., Green, V., England, J., & Greenman, J. (2017). The Role of Chemokines in Thyroid Carcinoma. Thyroid : official journal of the American Thyroid Association, 27(11), 1347-1359. https://doi.org/10.1089/thy.2016.0660

• Journal Article Type: Article
• Acceptance Date: Aug 31, 2017
• Online Publication Date: Oct 16, 2017
• Publication Date: Nov 1, 2017
• Deposit Date: Nov 22, 2017
• Publicly Available Date: Oct 17, 2018
• Journal: Thyroid
• Print ISSN: 1050-7256
• Publisher: Mary Ann Liebert
• Peer Reviewed: Peer Reviewed
• Volume: 27
• Issue: 11
• Pages: 1347-1359
• DOI: https://doi.org/10.1089/thy.2016.0660
• Keywords: Endocrinology, Diabetes and Metabolism; Endocrinology
• Public URL: https://hull-repository.worktribe.com/output/368357
• Publisher URL: http://online.liebertpub.com/doi/10.1089/thy.2016.0660
• Additional Information: Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/thy.2016.0660
• Contract Date: Nov 22, 2017