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The Role of Chemokines in Thyroid Carcinoma

Yapa, Sharinie; Mulla, Omar; Green, Victoria; England, James; Greenman, John

Authors

Sharinie Yapa

Omar Mulla

Victoria Green

James England

Abstract

© Copyright 2017, Mary Ann Liebert, Inc. 2017. The global incidence of thyroid cancer is increasing, and metastatic spread to the lymph nodes is common in papillary thyroid carcinoma. The metastatic course of thyroid carcinoma is an intricate process involving invasion, angiogenesis, cell trafficking, extravasation, organ specific homing, and growth. A key aspect in this process involves a multitude of interactions between chemokines and their receptors. Chemokines are a group of small proteins, which act to elicit normal physiologic and immune responses principally through recruitment of specific cell populations to the site of infection or malignancy. Thyroid cancer cells, like other tumors, possess the ability to corrupt the chemokine system to their advantage by altering cell movement into the tumor microenvironment and affecting all aspects of thyroid cancer progression.

Journal Article Type Article
Publication Date Nov 1, 2017
Journal Thyroid
Print ISSN 1050-7256
Electronic ISSN 1557-9077
Publisher Mary Ann Liebert
Peer Reviewed Peer Reviewed
Volume 27
Issue 11
Pages 1347-1359
Institution Citation Yapa, S., Mulla, O., Green, V., England, J., & Greenman, J. (2017). The Role of Chemokines in Thyroid Carcinoma. Thyroid : official journal of the American Thyroid Association, 27(11), 1347-1359. doi:10.1089/thy.2016.0660
DOI https://doi.org/10.1089/thy.2016.0660
Keywords Endocrinology, Diabetes and Metabolism; Endocrinology
Publisher URL http://online.liebertpub.com/doi/10.1089/thy.2016.0660
Additional Information Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/thy.2016.0660

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