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Circadian variation of human ventricular fibrillation dominant frequency

Langley, Philip; MacGowan, Guy A.; Murray, Alan


Guy A. MacGowan

Alan Murray


Circadian variation in human ventricular fibrillation (VF) dominant frequency is unknown. If present this would provide evidence of physiological influence on VF. The objective was to quantify the circadian variation in human VF dominant frequency.
Eight-lead Holter ECG recordings were obtained from a patient with severe myocarditis and chronic VF who was supported by a biventricular assist device. Recordings of up to 24h duration were obtained on 6 days with an average interval between recordings of 7 days. Dominant frequency and amplitude were obtained using spectral analysis and assessed for (i) circadian (ii) inter-recording and (iii) inter-lead differences.
There was a significant circadian variation in amplitude (night: 0.027±0.004mVHz vs day: 0.044±0.006mVHz, p0.05). There were significant differences between recordings in dominant frequency which ranged from 6.80±0.29Hz to 8.36±0.38Hz (p

Journal Article Type Article
Publication Date 2010-08
Journal Resuscitation
Print ISSN 0300-9572
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 81
Issue 8
Pages 950-955
APA6 Citation Langley, P., MacGowan, G. A., & Murray, A. (2010). Circadian variation of human ventricular fibrillation dominant frequency. Resuscitation, 81(8), (950-955). doi:10.1016/j.resuscitation.2010.03.026. ISSN 0300-9572
Keywords Ventricular fibrillation; Dominant frequency; Circadian variability