Jitendra Nandre
A novel fluorescent "turn-on" chemosensor for nanomolar detection of Fe(III) from aqueous solution and its application in living cells imaging
Nandre, Jitendra; Patil, Samadhan; Patil, Vijay; Yu, Fabiao; Chen, Lingxin; Sahoo, Suban; Prior, Timothy; Redshaw, Carl; Mahulikar, Pramod; Patil, Umesh
Authors
Samadhan Patil
Vijay Patil
Fabiao Yu
Lingxin Chen
Suban Sahoo
Dr Tim Prior T.Prior@hull.ac.uk
Senior Lecturer in Inorganic Chemistry
Professor Carl Redshaw C.Redshaw@hull.ac.uk
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry
Pramod Mahulikar
Umesh Patil
Abstract
An electronically active and spectral sensitive fluorescent “turn-on” chemosensor (BTP-1) based on the benzo-thiazolo-pyrimidine unit was designed and synthesized for the highly selective and sensitive detection of Fe³⁺ from aqueous medium. With Fe³⁺, the sensor BTP-1 showed a remarkable fluorescence enhancement at 554 nm (λex=314 nm) due to the inhibition of photo-induced electron transfer. The sensor formed a host-guest complex in 1:1 stoichiometry with the detection limit down to 0.74 nM. Further, the sensor was successfully utilized for the qualitative and quantitative intracellular detection of Fe³⁺ in two liver cell lines i.e., HepG2 cells (human hepatocellular liver carcinoma cell line) and HL-7701 cells (human normal liver cell line) by a confocal imaging technique.
Citation
Nandre, J., Patil, S., Patil, V., Yu, F., Chen, L., Sahoo, S., Prior, T., Redshaw, C., Mahulikar, P., & Patil, U. (2014). A novel fluorescent "turn-on" chemosensor for nanomolar detection of Fe(III) from aqueous solution and its application in living cells imaging. Biosensors & bioelectronics, 61(November), 612-617. https://doi.org/10.1016/j.bios.2014.06.017
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 10, 2014 |
Online Publication Date | Jun 14, 2014 |
Publication Date | Nov 15, 2014 |
Deposit Date | Jun 30, 2015 |
Publicly Available Date | Jun 30, 2015 |
Journal | Biosensors & bioelectronics |
Print ISSN | 0956-5663 |
Electronic ISSN | 1873-4235 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 61 |
Issue | November |
Pages | 612-617 |
DOI | https://doi.org/10.1016/j.bios.2014.06.017 |
Keywords | Fluorescent “turn-on” sensor, Benzo-thiazolo-pyrimidine, Fe³⁺, ICT, PET, Live cells imaging |
Public URL | https://hull-repository.worktribe.com/output/375900 |
Publisher URL | http://www.sciencedirect.com/science/article/pii/S0956566314004308 |
Additional Information | Author's accepted manuscript of article published in: Biosensors & bioelectronics, 2014, v.61, November. |
Contract Date | Jun 30, 2015 |
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Copyright Statement
© 2014, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
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