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A novel fluorescent "turn-on" chemosensor for nanomolar detection of Fe(III) from aqueous solution and its application in living cells imaging

Patil, U.; Patil, S.; Mahulikar, P.; Sahoo, S.; Chen, L.; Yu, F.; Patil, V.; Nandre, J.; Nandre, Jitendra; Patil, Samadhan; Patil, Vijay; Yu, Fabiao; Chen, Lingxin; Sahoo, Suban; Prior, Timothy; Redshaw, Carl; Mahulikar, Pramod; Patil, Umesh


U. Patil

S. Patil

P. Mahulikar

S. Sahoo

L. Chen

F. Yu

V. Patil

J. Nandre

Jitendra Nandre

Samadhan Patil

Vijay Patil

Fabiao Yu

Lingxin Chen

Suban Sahoo

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Professor Carl Redshaw
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry

Pramod Mahulikar

Umesh Patil


An electronically active and spectral sensitive fluorescent “turn-on” chemosensor (BTP-1) based on the benzo-thiazolo-pyrimidine unit was designed and synthesized for the highly selective and sensitive detection of Fe³⁺ from aqueous medium. With Fe³⁺, the sensor BTP-1 showed a remarkable fluorescence enhancement at 554 nm (λex=314 nm) due to the inhibition of photo-induced electron transfer. The sensor formed a host-guest complex in 1:1 stoichiometry with the detection limit down to 0.74 nM. Further, the sensor was successfully utilized for the qualitative and quantitative intracellular detection of Fe³⁺ in two liver cell lines i.e., HepG2 cells (human hepatocellular liver carcinoma cell line) and HL-7701 cells (human normal liver cell line) by a confocal imaging technique.


Nandre, J., Patil, S., Patil, V., Yu, F., Chen, L., Sahoo, S., …Patil, U. (2014). A novel fluorescent "turn-on" chemosensor for nanomolar detection of Fe(III) from aqueous solution and its application in living cells imaging. Biosensors & bioelectronics, 61(November), 612-617.

Journal Article Type Article
Acceptance Date Jun 10, 2014
Online Publication Date Jun 14, 2014
Publication Date Nov 15, 2014
Deposit Date Jun 30, 2015
Publicly Available Date Jun 30, 2015
Journal Biosensors & bioelectronics
Print ISSN 0956-5663
Electronic ISSN 1873-4235
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 61
Issue November
Pages 612-617
Keywords Fluorescent “turn-on” sensor, Benzo-thiazolo-pyrimidine, Fe³⁺, ICT, PET, Live cells imaging
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Copyright Statement © 2014, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Additional Information Author's accepted manuscript of article published in: Biosensors & bioelectronics, 2014, v.61, November.


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