U. Patil
A novel fluorescent "turn-on" chemosensor for nanomolar detection of Fe(III) from aqueous solution and its application in living cells imaging
Patil, U.; Patil, S.; Mahulikar, P.; Sahoo, S.; Chen, L.; Yu, F.; Patil, V.; Nandre, J.; Nandre, Jitendra; Patil, Samadhan; Patil, Vijay; Yu, Fabiao; Chen, Lingxin; Sahoo, Suban; Prior, Timothy; Redshaw, Carl; Mahulikar, Pramod; Patil, Umesh
Authors
S. Patil
P. Mahulikar
S. Sahoo
L. Chen
F. Yu
V. Patil
J. Nandre
Jitendra Nandre
Samadhan Patil
Vijay Patil
Fabiao Yu
Lingxin Chen
Suban Sahoo
Dr Timothy Prior T.Prior@hull.ac.uk
Senior Lecturer in Inorganic Chemistry
Professor Carl Redshaw C.Redshaw@hull.ac.uk
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry
Pramod Mahulikar
Umesh Patil
Abstract
An electronically active and spectral sensitive fluorescent “turn-on” chemosensor (BTP-1) based on the benzo-thiazolo-pyrimidine unit was designed and synthesized for the highly selective and sensitive detection of Fe³⁺ from aqueous medium. With Fe³⁺, the sensor BTP-1 showed a remarkable fluorescence enhancement at 554 nm (λex=314 nm) due to the inhibition of photo-induced electron transfer. The sensor formed a host-guest complex in 1:1 stoichiometry with the detection limit down to 0.74 nM. Further, the sensor was successfully utilized for the qualitative and quantitative intracellular detection of Fe³⁺ in two liver cell lines i.e., HepG2 cells (human hepatocellular liver carcinoma cell line) and HL-7701 cells (human normal liver cell line) by a confocal imaging technique.
Citation
Nandre, J., Patil, S., Patil, V., Yu, F., Chen, L., Sahoo, S., …Patil, U. (2014). A novel fluorescent "turn-on" chemosensor for nanomolar detection of Fe(III) from aqueous solution and its application in living cells imaging. Biosensors & bioelectronics, 61(November), 612-617. https://doi.org/10.1016/j.bios.2014.06.017
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 10, 2014 |
Online Publication Date | Jun 14, 2014 |
Publication Date | Nov 15, 2014 |
Deposit Date | Jun 30, 2015 |
Publicly Available Date | Jun 30, 2015 |
Journal | Biosensors & bioelectronics |
Print ISSN | 0956-5663 |
Electronic ISSN | 1873-4235 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 61 |
Issue | November |
Pages | 612-617 |
DOI | https://doi.org/10.1016/j.bios.2014.06.017 |
Keywords | Fluorescent “turn-on” sensor, Benzo-thiazolo-pyrimidine, Fe³⁺, ICT, PET, Live cells imaging |
Public URL | https://hull-repository.worktribe.com/output/375900 |
Publisher URL | http://www.sciencedirect.com/science/article/pii/S0956566314004308 |
Additional Information | Author's accepted manuscript of article published in: Biosensors & bioelectronics, 2014, v.61, November. |
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Publisher Licence URL
http://creativecommons.org/licenses/by-nc-nd/4.0/
Copyright Statement
© 2014, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
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