A study of allosteric binding behaviour of a 1,3-alternate thiacalix[4]arene-based receptor using fluorescence signal

Tomiyasu, Hirotsugu; Jin, Cheng-Cheng; Ni, Xin-Long; Zeng, Xi; Redshaw, Carl; Yamato, Takehiko

Abstract

A novel heteroditopic thiacalix[4]arene receptor L possessing 1,3-alternate conformation, which contains two pyrene moieties attached to the lower rim via urea linkages together with a crown ether moiety appended at the opposite side of the thiacalix[4]arene cavity, has been synthesized. The complexation behaviour of receptor L was studied by means of fluorescence spectra and ¹H NMR titration experiments in the presence of K⁺ ions and a variety of other anions. The results suggested that receptor L can complex efficiently via the urea cavity or the crown ether moiety, and a positive/negative allosteric effect operating in receptor L was observed.

Citation

Tomiyasu, H., Jin, C.-C., Ni, X.-L., Zeng, X., Redshaw, C., & Yamato, T. (2014). A study of allosteric binding behaviour of a 1,3-alternate thiacalix[4]arene-based receptor using fluorescence signal. Organic & biomolecular chemistry, 12(27), 4917-4923. https://doi.org/10.1039/c4ob00551a

• Journal Article Type: Article
• Acceptance Date: May 9, 2014
• Online Publication Date: May 12, 2014
• Publication Date: Jul 21, 2014
• Deposit Date: Jul 8, 2015
• Publicly Available Date: Jul 8, 2015
• Journal: Organic & biomolecular chemistry
• Print ISSN: 1477-0520
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Issue: 27
• Pages: 4917-4923
• DOI: https://doi.org/10.1039/c4ob00551a
• Keywords: Fluorescence signal, Allosteric binding behaviour
• Public URL: https://hull-repository.worktribe.com/output/376133
• Publisher URL: http://pubs.rsc.org/en/Content/ArticleLanding/2014/OB/c4ob00551a#!divAbstract
• Additional Information: Author's accepted manuscript of article published in: Organic & biomolecular chemistry, 2014, v.12, issue 27.
• Contract Date: Jul 8, 2015