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A study of allosteric binding behaviour of a 1,3-alternate thiacalix[4]arene-based receptor using fluorescence signal

Tomiyasu, Hirotsugu; Jin, Cheng Cheng; Jin, Cheng-Cheng; Ni, Xin Long; Ni, Xin-Long; Zeng, Xi; Redshaw, Carl; Yamato, Takehiko

Authors

Hirotsugu Tomiyasu

Cheng Cheng Jin

Cheng-Cheng Jin

Xin Long Ni

Xin-Long Ni

Xi Zeng

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Professor Carl Redshaw C.Redshaw@hull.ac.uk
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry

Takehiko Yamato



Abstract

A novel heteroditopic thiacalix[4]arene receptor L possessing 1,3-alternate conformation, which contains two pyrene moieties attached to the lower rim via urea linkages together with a crown ether moiety appended at the opposite side of the thiacalix[4]arene cavity, has been synthesized. The complexation behaviour of receptor L was studied by means of fluorescence spectra and ¹H NMR titration experiments in the presence of K⁺ ions and a variety of other anions. The results suggested that receptor L can complex efficiently via the urea cavity or the crown ether moiety, and a positive/negative allosteric effect operating in receptor L was observed.

Citation

Tomiyasu, H., Jin, C., Ni, X., Zeng, X., Redshaw, C., & Yamato, T. (2014). A study of allosteric binding behaviour of a 1,3-alternate thiacalix[4]arene-based receptor using fluorescence signal. Organic & biomolecular chemistry, 12(27), 4917-4923. https://doi.org/10.1039/c4ob00551a

Journal Article Type Article
Acceptance Date May 9, 2014
Online Publication Date May 12, 2014
Publication Date Jul 21, 2014
Deposit Date Jul 8, 2015
Publicly Available Date Jul 8, 2015
Journal Organic & biomolecular chemistry
Print ISSN 1477-0520
Electronic ISSN 1477-0539
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 12
Issue 27
Pages 4917-4923
DOI https://doi.org/10.1039/c4ob00551a
Keywords Fluorescence signal, Allosteric binding behaviour
Public URL https://hull-repository.worktribe.com/output/376133
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2014/OB/c4ob00551a#!divAbstract
Copyright Statement ©2015 University of Hull
Additional Information Author's accepted manuscript of article published in: Organic & biomolecular chemistry, 2014, v.12, issue 27.

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