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A study of allosteric binding behaviour of a 1,3-alternate thiacalix[4]arene-based receptor using fluorescence signal

Tomiyasu, Hirotsugu; Jin, Cheng Cheng; Jin, Cheng-Cheng; Ni, Xin Long; Ni, Xin-Long; Zeng, Xi; Redshaw, Carl; Yamato, Takehiko

Authors

Hirotsugu Tomiyasu

Cheng Cheng Jin

Cheng-Cheng Jin

Xin Long Ni

Xin-Long Ni

Xi Zeng

Professor Carl Redshaw C.Redshaw@hull.ac.uk
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry

Takehiko Yamato

Abstract

A novel heteroditopic thiacalix[4]arene receptor L possessing 1,3-alternate conformation, which contains two pyrene moieties attached to the lower rim via urea linkages together with a crown ether moiety appended at the opposite side of the thiacalix[4]arene cavity, has been synthesized. The complexation behaviour of receptor L was studied by means of fluorescence spectra and ¹H NMR titration experiments in the presence of K⁺ ions and a variety of other anions. The results suggested that receptor L can complex efficiently via the urea cavity or the crown ether moiety, and a positive/negative allosteric effect operating in receptor L was observed.

Journal Article Type Article
Publication Date Jul 21, 2014
Journal Organic & biomolecular chemistry
Print ISSN 1477-0520
Electronic ISSN 1477-0539
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 12
Issue 27
Pages 4917-4923
Institution Citation Tomiyasu, H., Jin, C., Ni, X., Zeng, X., Redshaw, C., & Yamato, T. (2014). A study of allosteric binding behaviour of a 1,3-alternate thiacalix[4]arene-based receptor using fluorescence signal. Organic & biomolecular chemistry, 12(27), 4917-4923. https://doi.org/10.1039/c4ob00551a
DOI https://doi.org/10.1039/c4ob00551a
Keywords Fluorescence signal, Allosteric binding behaviour
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2014/OB/c4ob00551a#!divAbstract
Copyright Statement ©2015 University of Hull
Additional Information Author's accepted manuscript of article published in: Organic & biomolecular chemistry, 2014, v.12, issue 27.

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