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Immobilized photosensitizers for antimicrobial applications

Spagnul, Cinzia; Turner, Lauren C.; Boyle, Ross W.

Authors

Cinzia Spagnul

Lauren C. Turner

Ross W. Boyle



Abstract

Photodynamic antimicrobial chemotherapy (PACT) is a very promising alternative to conventional antibiotics for the efficient inactivation of pathogenic microorganisms; this is due to the fact that it is virtually impossible for resistant strains to develop due to the mode of action employed. PACT employs a photosensitizer, which preferentially associates with the microorganism, and is then activated with non-thermal visible light of appropriate wavelength(s) to generate high localized concentrations of reactive oxygen species (ROS), inactivating the microorganism. The concept of using photosensitizers immobilized on a surface for this purpose is intended to address a range of economic, ecological and public health issues. Photosensitising molecules that have been immobilized on solid support for PACT applications are described herein. Different supports have been analyzed as well as the target microorganism and the effectiveness of particular combinations of support and photosensitiser.

Citation

Spagnul, C., Turner, L. C., & Boyle, R. W. (2015). Immobilized photosensitizers for antimicrobial applications. Journal of photochemistry and photobiology. B, Biology, 150(September), 11-30 . https://doi.org/10.1016/j.jphotobiol.2015.04.021

Journal Article Type Article
Acceptance Date Apr 19, 2015
Online Publication Date May 2, 2015
Publication Date 2015-09
Deposit Date Aug 27, 2015
Publicly Available Date Nov 23, 2017
Journal Journal of photochemistry and photobiology B: biology
Print ISSN 1011-1344
Electronic ISSN 1873-2682
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 150
Issue September
Pages 11-30
DOI https://doi.org/10.1016/j.jphotobiol.2015.04.021
Keywords Photodynamic antimicrobial chemotherapy; Pathogen inactivation; Photosensitizer immobilized; Disinfection; Reactive oxygen species
Public URL https://hull-repository.worktribe.com/output/378156
Publisher URL http://www.sciencedirect.com/science/article/pii/S101113441500144X
Additional Information Author's accepted manuscript of article published in: Journal of photochemistry and photobiology B: biology, 2015, v.150, September.

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