Immobilized photosensitizers for antimicrobial applications

Spagnul, Cinzia; Turner, Lauren C.; Boyle, Ross W.

Abstract

Photodynamic antimicrobial chemotherapy (PACT) is a very promising alternative to conventional antibiotics for the efficient inactivation of pathogenic microorganisms; this is due to the fact that it is virtually impossible for resistant strains to develop due to the mode of action employed. PACT employs a photosensitizer, which preferentially associates with the microorganism, and is then activated with non-thermal visible light of appropriate wavelength(s) to generate high localized concentrations of reactive oxygen species (ROS), inactivating the microorganism. The concept of using photosensitizers immobilized on a surface for this purpose is intended to address a range of economic, ecological and public health issues. Photosensitising molecules that have been immobilized on solid support for PACT applications are described herein. Different supports have been analyzed as well as the target microorganism and the effectiveness of particular combinations of support and photosensitiser.

Citation

Spagnul, C., Turner, L. C., & Boyle, R. W. (2015). Immobilized photosensitizers for antimicrobial applications. Journal of photochemistry and photobiology. B, Biology, 150(September), 11-30. https://doi.org/10.1016/j.jphotobiol.2015.04.021

• Journal Article Type: Article
• Acceptance Date: Apr 19, 2015
• Online Publication Date: May 2, 2015
• Publication Date: 2015-09
• Deposit Date: Aug 27, 2015
• Publicly Available Date: Nov 23, 2017
• Journal: Journal of photochemistry and photobiology B: biology
• Print ISSN: 1011-1344
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 150
• Issue: September
• Pages: 11-30
• DOI: https://doi.org/10.1016/j.jphotobiol.2015.04.021
• Keywords: Photodynamic antimicrobial chemotherapy; Pathogen inactivation; Photosensitizer immobilized; Disinfection; Reactive oxygen species
• Public URL: https://hull-repository.worktribe.com/output/378156
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S101113441500144X
• Additional Information: Author's accepted manuscript of article published in: Journal of photochemistry and photobiology B: biology, 2015, v.150, September.
• Contract Date: Nov 23, 2017