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Immobilized photosensitizers for antimicrobial applications

Spagnul, Cinzia; Turner, Lauren C.; Boyle, Ross W.

Authors

Cinzia Spagnul

Lauren C. Turner

Professor Ross Boyle R.W.Boyle@hull.ac.uk
Professor of Biological Chemistry/ Module Coordinator for Biological Macromolecules/ Biological Safety and Genetic Modifications Committee Member

Abstract

Photodynamic antimicrobial chemotherapy (PACT) is a very promising alternative to conventional antibiotics for the efficient inactivation of pathogenic microorganisms; this is due to the fact that it is virtually impossible for resistant strains to develop due to the mode of action employed. PACT employs a photosensitizer, which preferentially associates with the microorganism, and is then activated with non-thermal visible light of appropriate wavelength(s) to generate high localized concentrations of reactive oxygen species (ROS), inactivating the microorganism. The concept of using photosensitizers immobilized on a surface for this purpose is intended to address a range of economic, ecological and public health issues. Photosensitising molecules that have been immobilized on solid support for PACT applications are described herein. Different supports have been analyzed as well as the target microorganism and the effectiveness of particular combinations of support and photosensitiser.

Journal Article Type Article
Publication Date 2015-09
Journal Journal of photochemistry and photobiology B: biology
Print ISSN 1011-1344
Electronic ISSN 1873-2682
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 150
Issue September
Pages 11-30
Institution Citation Spagnul, C., Turner, L. C., & Boyle, R. W. (2015). Immobilized photosensitizers for antimicrobial applications. Journal of photochemistry and photobiology. B, Biology, 150(September), 11-30. https://doi.org/10.1016/j.jphotobiol.2015.04.021
DOI https://doi.org/10.1016/j.jphotobiol.2015.04.021
Keywords Photodynamic antimicrobial chemotherapy; Pathogen inactivation; Photosensitizer immobilized; Disinfection; Reactive oxygen species
Publisher URL http://www.sciencedirect.com/science/article/pii/S101113441500144X
Additional Information Author's accepted manuscript of article published in: Journal of photochemistry and photobiology B: biology, 2015, v.150, September.

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© 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/




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