Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart

Walton, Richard D.; Jones, Sandra A.; Rostron, Kerry A.; Kayani, Anna C.; Close, Graeme L.; McArdle, Anne; Lancaster, Matthew K.

Abstract

With aging, there is a decline in cardiac function accompanying increasing risk of arrhythmias. These effects are likely to be mechanistically associated with age-associated changes in calcium regulation within cardiac myocytes. Previous studies suggest that lifelong exercise can potentially reduce age-associated changes in the heart. Although exercise itself is associated with changes in cardiac function, little is known about the interactions of aging and exercise with respect to myocyte calcium regulation. To investigate this, adult (12 months) and old (24 months) C57/Bl6 mice were trained using moderate-intensity treadmill running. In response to 10 weeks’ training, comparable cardiac hypertrophic responses were observed, although aging independently associated with additional cardiac hypertrophy. Old animals also showed increased L- and T-type calcium channels, the sodium–calcium exchange, sarcoendoplasmic reticulum calcium ATPase, and collagen (by 50%, 92%, 66%, 88%, and 113% respectively). Short-term exercise training increased D-type and T-type calcium channels in old animals only, whereas an increase in sodium–calcium exchange was seen only in adult animals. Long-term (12 months) training generally opposed the effects of aging. Significant hypertrophy remained in long-term trained old animals, but levels of sarcoendoplasmic reticulum calcium ATPase, sodium–calcium exchange, and collagen were not significantly different from those found in the adult trained animals.

Citation

Walton, R. D., Jones, S. A., Rostron, K. A., Kayani, A. C., Close, G. L., McArdle, A., & Lancaster, M. K. (2016). Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart. The journals of gerontology. Series A, Biological sciences and medical sciences, 71(8), 1005-1013. https://doi.org/10.1093/gerona/glv093

• Journal Article Type: Article
• Acceptance Date: May 22, 2015
• Online Publication Date: Aug 5, 2015
• Publication Date: Aug 1, 2016
• Deposit Date: Oct 21, 2015
• Publicly Available Date: Nov 23, 2017
• Journal: Journals of gerontology, series a : biological sciences & medical sciences
• Print ISSN: 1079-5006
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 71
• Issue: 8
• Pages: 1005-1013
• DOI: https://doi.org/10.1093/gerona/glv093
• Keywords: Aging; Exercise; Fibrosis; Calcium regulation; Hypertrophy
• Public URL: https://hull-repository.worktribe.com/output/379836
• Publisher URL: http://biomedgerontology.oxfordjournals.org/content/early/2015/08/05/gerona.glv093
• Additional Information: Gold open access article published in: Journals of gerontology : biological sciences, 2015, v.71 issue 8.
• Contract Date: Nov 23, 2017