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Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart

Walton, Richard D.; Jones, Sandra A.; Rostron, Kerry A.; Kayani, Anna C.; Close, Graeme L.; McArdle, Anne; Lancaster, Matthew K.


Richard D. Walton

Kerry A. Rostron

Anna C. Kayani

Graeme L. Close

Anne McArdle

Matthew K. Lancaster


With aging, there is a decline in cardiac function accompanying increasing risk of arrhythmias. These effects are likely to be mechanistically associated with age-associated changes in calcium regulation within cardiac myocytes. Previous studies suggest that lifelong exercise can potentially reduce age-associated changes in the heart. Although exercise itself is associated with changes in cardiac function, little is known about the interactions of aging and exercise with respect to myocyte calcium regulation. To investigate this, adult (12 months) and old (24 months) C57/Bl6 mice were trained using moderate-intensity treadmill running. In response to 10 weeks’ training, comparable cardiac hypertrophic responses were observed, although aging independently associated with additional cardiac hypertrophy. Old animals also showed increased L- and T-type calcium channels, the sodium–calcium exchange, sarcoendoplasmic reticulum calcium ATPase, and collagen (by 50%, 92%, 66%, 88%, and 113% respectively). Short-term exercise training increased D-type and T-type calcium channels in old animals only, whereas an increase in sodium–calcium exchange was seen only in adult animals. Long-term (12 months) training generally opposed the effects of aging. Significant hypertrophy remained in long-term trained old animals, but levels of sarcoendoplasmic reticulum calcium ATPase, sodium–calcium exchange, and collagen were not significantly different from those found in the adult trained animals.


Walton, R. D., Jones, S. A., Rostron, K. A., Kayani, A. C., Close, G. L., McArdle, A., & Lancaster, M. K. (2016). Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart. The journals of gerontology. Series A, Biological sciences and medical sciences, 71(8), 1005-1013.

Journal Article Type Article
Acceptance Date May 22, 2015
Online Publication Date Aug 5, 2015
Publication Date Aug 1, 2016
Deposit Date Oct 21, 2015
Publicly Available Date Nov 23, 2017
Journal Journals of gerontology, series a : biological sciences & medical sciences
Print ISSN 1079-5006
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 71
Issue 8
Pages 1005-1013
Keywords Aging; Exercise; Fibrosis; Calcium regulation; Hypertrophy
Public URL
Publisher URL
Additional Information Gold open access article published in: Journals of gerontology : biological sciences, 2015, v.71 issue 8.
Contract Date Nov 23, 2017


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Copyright Statement
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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