Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?

Moin, Abu Saleh Md; Al-Qaissi, Ahmed; Sathyapalan, Thozhukat; Atkin, Stephen L.; Butler, Alexandra E.

doi:10.3389/fendo.2021.665134

Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?

Moin, Abu Saleh Md; Al-Qaissi, Ahmed; Sathyapalan, Thozhukat; Atkin, Stephen L.; Butler, Alexandra E.

Authors

Abu Saleh Md Moin

Ahmed Al-Qaissi

Professor Thozhukat Sathyapalan T.Sathyapalan@hull.ac.uk
Professor of Diabetes, Endocrinology and Metabolism

Stephen L. Atkin

Alexandra E. Butler

Abstract

Introduction: Neuropilin-1(NRP1) is a cofactor that enhances SARS-CoV-2 coronavirus cell infectivity when co-expressed with angiotensin-converting enzyme 2(ACE2). The Renin-Angiotensin System (RAS) is activated in type 2 diabetes (T2D); therefore, the aim of this study was to determine if hypoglycaemia-induced stress in T2D would potentiate serum NRP1(sNRP1) levels, reflecting an increased risk for SARS-CoV-2 infection. Methods: A case-control study of aged-matched T2D (n = 23) and control (n = 23) subjects who underwent a hyperinsulinemic clamp over 1-hour to hypoglycemia(

Citation

Moin, A. S. M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?. Frontiers in endocrinology, 12, Article 665134. https://doi.org/10.3389/fendo.2021.665134

Journal Article Type	Article
Acceptance Date	Jun 8, 2021
Online Publication Date	Jun 23, 2021
Publication Date	Jun 23, 2021
Deposit Date	Oct 1, 2021
Publicly Available Date	Oct 7, 2021
Journal	Frontiers in Endocrinology
Print ISSN	1664-2392
Electronic ISSN	1664-2392
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	12
Article Number	665134
DOI	https://doi.org/10.3389/fendo.2021.665134
Keywords	Neuropilin-1; Type 2 diabetes; COVID-19; SARS-CoV-2; ACE inhibitors; ADAM9
Public URL	https://hull-repository.worktribe.com/output/3805016

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Copyright Statement
© 2021 Moin, Al-Qaissi, Sathyapalan, Atkin and Butler. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.