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Nutrient regulation of inflammatory signalling in obesity and vascular disease

Palmer, Timothy M.; Salt, Ian P.

Authors

Ian P. Salt



Abstract

Despite obesity and diabetes markedly increasing the risk of developing cardiovascular diseases, the molecular and cellular mechanisms that underlie this association remain poorly characterised. In the last 20 years it has become apparent that chronic, low-grade inflammation in obese adipose tissue may contribute to the risk of developing insulin resistance and type 2 diabetes. Furthermore, increased vascular pro-inflammatory signalling is a key event in the development of cardiovascular diseases. Overnutrition exacerbates pro-inflammatory signalling in vascular and adipose tissues, with several mechanisms proposed to mediate this. In this article, we review the molecular and cellular mechanisms by which nutrients are proposed to regulate pro-inflammatory signalling in adipose and vascular tissues. In addition, we examine the potential therapeutic opportunities that these mechanisms provide for suppression of inappropriate inflammation in obesity and vascular disease.

Citation

Palmer, T. M., & Salt, I. P. (2021). Nutrient regulation of inflammatory signalling in obesity and vascular disease. Clinical Science, 135(13), 1563-1590. https://doi.org/10.1042/CS20190768

Journal Article Type Review
Acceptance Date Jun 28, 2021
Online Publication Date Jul 7, 2021
Publication Date 2021-07
Deposit Date Aug 5, 2021
Publicly Available Date Mar 29, 2024
Journal Clinical Science
Print ISSN 0143-5221
Electronic ISSN 1470-8736
Publisher Portland Press
Peer Reviewed Peer Reviewed
Volume 135
Issue 13
Pages 1563-1590
DOI https://doi.org/10.1042/CS20190768
Keywords Cardiovascular disease; Hyperglycaemia; Inflammation; Obesity
Public URL https://hull-repository.worktribe.com/output/3805171

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Copyright Statement
Copyright © 2021 The Authors. This is the author’s final accepted version. There may be differences between this version and the published version. You are advised to consult the publisher’s version if you wish to cite from it.





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