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Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma

Stafford, Nicholas D.; Wong, B. Y. Winson; Green, Victoria L.; Greenman, John

Authors

Nicholas D. Stafford

B. Y. Winson Wong

Victoria L. Green



Abstract

© 2015 Wiley Periodicals, Inc.. Background The neutrophil/lymphocyte ratio (NLR) has been found to be predictive of survival outcome in a range of tumors. The purpose of this study was to investigate the prognostic value of pretreatment (NLR) in patients with laryngeal squamous cell carcinoma (SCC). Methods A retrospective analysis of 140 patients with laryngeal SCC treated between 2005 and 2010 in the Hull and East Yorkshire Hospitals NHS Trust was carried out. Patient records were evaluated and both pretreatment neutrophil and lymphocyte counts were documented together with survival data, sex, smoking status, nodal classification, and disease staging. Results An elevated NLR was significantly associated with advanced disease stage (eg, node-positive and tumors stage III and IV). In addition, a high NLR was significantly associated with poor overall survival (OS) but not disease-free survival (DFS) on multivariate analysis, with the greatest significance seen in patients with the highest NLR. Conclusion Pretreatment NLR may serve as a useful prognostic marker in laryngeal SCC; however, a large prospective study is required to determine an optimal NLR cutoff value.

Journal Article Type Article
Publication Date Apr 1, 2016
Journal Head & neck
Print ISSN 1043-3074
Electronic ISSN 1097-0347
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 38
Issue S1
Pages E1903-E1908
APA6 Citation Wong, B. Y. W., Stafford, N. D., Green, V. L., & Greenman, J. (2016). Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma. Head & neck, 38(S1), E1903-E1908. doi:10.1002/hed.24346
DOI https://doi.org/10.1002/hed.24346
Keywords Neutrophils, Lymphocytes, Laryngeal cancer, Survival, Prognosis
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/hed.24346/abstract
Additional Information This is the peer reviewed version of the following article: Wong, B. Y. W., Stafford, N. D., Green, V. L. and Greenman, J. (2016), Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma. Head Neck, 38: E1903–E1908. Cite this article, which has been published in final form at doi:10.1002/hed.24346. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

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