Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma

Wong, B. Y. Winson; Stafford, Nicholas D.; Green, Victoria L.; Greenman, John

Abstract

© 2015 Wiley Periodicals, Inc.. Background The neutrophil/lymphocyte ratio (NLR) has been found to be predictive of survival outcome in a range of tumors. The purpose of this study was to investigate the prognostic value of pretreatment (NLR) in patients with laryngeal squamous cell carcinoma (SCC). Methods A retrospective analysis of 140 patients with laryngeal SCC treated between 2005 and 2010 in the Hull and East Yorkshire Hospitals NHS Trust was carried out. Patient records were evaluated and both pretreatment neutrophil and lymphocyte counts were documented together with survival data, sex, smoking status, nodal classification, and disease staging. Results An elevated NLR was significantly associated with advanced disease stage (eg, node-positive and tumors stage III and IV). In addition, a high NLR was significantly associated with poor overall survival (OS) but not disease-free survival (DFS) on multivariate analysis, with the greatest significance seen in patients with the highest NLR. Conclusion Pretreatment NLR may serve as a useful prognostic marker in laryngeal SCC; however, a large prospective study is required to determine an optimal NLR cutoff value.

Citation

Wong, B. Y. W., Stafford, N. D., Green, V. L., & Greenman, J. (2016). Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma. Head & neck, 38(S1), E1903-E1908. https://doi.org/10.1002/hed.24346

• Journal Article Type: Article
• Acceptance Date: Oct 17, 2015
• Online Publication Date: Dec 26, 2015
• Publication Date: Apr 1, 2016
• Deposit Date: Feb 16, 2016
• Publicly Available Date: Feb 16, 2016
• Journal: Head & neck
• Print ISSN: 1043-3074
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 38
• Issue: S1
• Pages: E1903-E1908
• DOI: https://doi.org/10.1002/hed.24346
• Keywords: Neutrophils, Lymphocytes, Laryngeal cancer, Survival, Prognosis
• Public URL: https://hull-repository.worktribe.com/output/385521
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1002/hed.24346/abstract
• Additional Information: This is the peer reviewed version of the following article: Wong, B. Y. W., Stafford, N. D., Green, V. L. and Greenman, J. (2016), Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma. Head Neck, 38: E1903–E1908. Cite this article, which has been published in final form at doi:10.1002/hed.24346. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
• Contract Date: Feb 16, 2016