Gonadal atresia, estrogen-responsive, and apoptosis-specific mRNA expression in marine mussels from the East China coast: a preliminary study

Zhu, Jingmin; Li, Jiana; Chapman, Emma C.; Shi, Huahong; Ciocan, Corina M.; Chen, Kai; Shi, Xiaodong; Zhou, Jun Liang; Sun, Peiying; Zheng, Yueyao; Rotchell, Jeanette M.

doi:10.1007/s00128-022-03461-2

Gonadal atresia, estrogen-responsive, and apoptosis-specific mRNA expression in marine mussels from the East China coast: a preliminary study

Zhu, Jingmin; Li, Jiana; Chapman, Emma C.; Shi, Huahong; Ciocan, Corina M.; Chen, Kai; Shi, Xiaodong; Zhou, Jun Liang; Sun, Peiying; Zheng, Yueyao; Rotchell, Jeanette M.

Authors

Jingmin Zhu

Jiana Li

Emma C. Chapman

Huahong Shi

Corina M. Ciocan

Kai Chen

Xiaodong Shi

Jun Liang Zhou

Peiying Sun

Yueyao Zheng

Professor Jeanette Rotchell J.Rotchell@hull.ac.uk
Professor and Associate Dean for Research and Enterprise

Abstract

This preliminary survey analysed mussel atresia incidences, estrogen-responsive and apoptotic-specific molecular end points, and aqueous and gonadal levels of selected estrogens from the East China coast. Estrogen levels were low (e.g. < LOD-28.36ng/L, < LOD-3.88ng/g wet weight of tissue for BPA) relative to worldwide freshwater environments, but high oocyte follicle atresia incidences (up to 26.6%) occurred at selected sites. Expression of estrogen-responsive ER2 was significantly increased in males relative to females at sites with high atresia incidences in females. A second estrogen-responsive gene, V9, was significantly increased at two sites in April in females relative to males; the opposite was true for the remaining two sites. Apoptosis-specific genes (Bcl-2, fas) showed elevated expression in males relative to females at the site with the highest atresia incidence. These results provide coastal estrogen levels and the utility of several estrogen-specific molecular-level markers for marine mussels.

Citation

Zhu, J., Li, J., Chapman, E. C., Shi, H., Ciocan, C. M., Chen, K., Shi, X., Zhou, J. L., Sun, P., Zheng, Y., & Rotchell, J. M. (in press). Gonadal atresia, estrogen-responsive, and apoptosis-specific mRNA expression in marine mussels from the East China coast: a preliminary study. Bulletin of Environmental Contamination and Toxicology, https://doi.org/10.1007/s00128-022-03461-2

Journal Article Type	Article
Acceptance Date	Jan 11, 2022
Online Publication Date	Jan 24, 2022
Deposit Date	Jan 12, 2022
Publicly Available Date	Jan 31, 2022
Journal	Bulletin of Environmental Contamination and Toxicology
Print ISSN	0007-4861
Publisher	Springer (part of Springer Nature)
Peer Reviewed	Peer Reviewed
DOI	https://doi.org/10.1007/s00128-022-03461-2
Keywords	Mytilus; Estrogen; Atresia; Apoptosis
Public URL	https://hull-repository.worktribe.com/output/3910318

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