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Glycerol and galactose substituted zinc phthalocyanines. Synthesis and photodynamic activity

Zorlu, Yunus; Ermeydan, Mahmut Ali; Dumoulin, Fabienne; Ahsen, Vefa; Savoie, Huguette; Boyle, Ross W.

Authors

Yunus Zorlu

Mahmut Ali Ermeydan

Fabienne Dumoulin

Vefa Ahsen

Huguette Savoie



Abstract

Three novel water soluble, non-ionic, zinc phthalocyanines (Pcs) have been synthesized and their spectroscopic and photodynamic properties investigated in aqueous media. One of the three compounds was shown to be significantly less aggregated, when compared to the other two compounds, and this effect was found to be related to both the nature of the substituent, and also the position at which it is attached to the macrocycle. Photodynamic activity and cellular uptake by human adenocarcinoma cells (HT-29) was shown to be linked to the aggregation state of the Pcs in water.

Journal Article Type Article
Publication Date Mar 11, 2009
Journal PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
Print ISSN 1474-905X
Electronic ISSN 1474-9092
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 8
Issue 3
Pages 312-318
APA6 Citation Zorlu, Y., Ermeydan, M. A., Dumoulin, F., Ahsen, V., Savoie, H., & Boyle, R. W. (2009). Glycerol and galactose substituted zinc phthalocyanines. Synthesis and photodynamic activity. Photochemical & photobiological sciences : an international journal, 8(3), 312-318. https://doi.org/10.1039/b817348f
DOI https://doi.org/10.1039/b817348f
Keywords Physical and Theoretical Chemistry
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