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Concomitant hydrate polymorphism in the precipitation of sparfloxacin from aqueous solution

Llinas, Antonio; Prior, Timothy; Llinàs, Antonio; Burley, Jonathan C.; Prior, Timothy J.; Glen, Robert C.; Goodman, Jonathan M.

Authors

Antonio Llinas

Antonio Llinàs

Jonathan C. Burley

Robert C. Glen

Jonathan M. Goodman



Abstract

The Potentiometric Cycling for Polymorph Creation [PC](2) has been applied to sparfloxacin, a third-generation fluoroquinolone antibiotic. Two different trihydrate phases precipitate from aqueous solution. X-ray data indicate that one of these is a previously unknown polymorph of sparfloxacin trihydrate. Because both forms crystallize from solution at the same time, the two crystalline forms are concomitant polymorphs that precipitate in a thermodynamically controlled ratio.

Journal Article Type Article
Publication Date 2008
Journal CRYSTAL GROWTH & DESIGN
Print ISSN 1528-7483
Electronic ISSN 1528-7505
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 8
Issue 1
Pages 114-118
APA6 Citation Llinàs, A., Burley, J. C., Prior, T. J., Glen, R. C., & Goodman, J. M. (2008). Concomitant hydrate polymorphism in the precipitation of sparfloxacin from aqueous solution. Crystal growth & design, 8(1), 114-118. https://doi.org/10.1021/cg700908m
DOI https://doi.org/10.1021/cg700908m
Keywords General Materials Science; General Chemistry; Condensed Matter Physics
Publisher URL https://pubs.acs.org/doi/abs/10.1021/cg700908m