Concomitant hydrate polymorphism in the precipitation of sparfloxacin from aqueous solution

Llinas, Antonio; Prior, Timothy; Llinàs, Antonio; Burley, Jonathan C.; Prior, Timothy J.; Glen, Robert C.; Goodman, Jonathan M.

Abstract

The Potentiometric Cycling for Polymorph Creation [PC](2) has been applied to sparfloxacin, a third-generation fluoroquinolone antibiotic. Two different trihydrate phases precipitate from aqueous solution. X-ray data indicate that one of these is a previously unknown polymorph of sparfloxacin trihydrate. Because both forms crystallize from solution at the same time, the two crystalline forms are concomitant polymorphs that precipitate in a thermodynamically controlled ratio.

Citation

Llinàs, A., Burley, J. C., Prior, T. J., Glen, R. C., & Goodman, J. M. (2008). Concomitant hydrate polymorphism in the precipitation of sparfloxacin from aqueous solution. Crystal growth & design, 8(1), 114-118. https://doi.org/10.1021/cg700908m

• Journal Article Type: Article
• Online Publication Date: Jan 2, 2008
• Publication Date: 2008
• Journal: CRYSTAL GROWTH & DESIGN
• Print ISSN: 1528-7483
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 8
• Issue: 1
• Pages: 114-118
• DOI: https://doi.org/10.1021/cg700908m
• Keywords: General Materials Science; General Chemistry; Condensed Matter Physics
• Public URL: https://hull-repository.worktribe.com/output/396128
• Publisher URL: https://pubs.acs.org/doi/abs/10.1021/cg700908m