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On-chip pre-concentration and complexation of [18F]fluoride ions via regenerable anion exchange particles for radiochemical synthesis of Positron Emission Tomography tracers

De Leonardis, Francesco; Pascali, Giancarlo; Salvadori, Piero A.; Watts, Paul; Pamme, Nicole

Authors

Francesco De Leonardis

Giancarlo Pascali

Piero A. Salvadori

Paul Watts



Abstract

Microfluidic approaches have demonstrated a relevant impact on radiochemical reactions involving Positron Emission Tomography (PET) nuclides, due to shorter reaction times and smaller precursor quantities. However, little attention has been given to the integration of the initial pre-concentration and drying of radioactive [F-18]fluoride ions, required for the labeling of radiotracer compounds. In this work we report the design, fabrication and implementation of a glass microfluidic device filled with recyclable anion exchange particles for the repeated recovery of [F-18] and [F-19]fluoride ions. The device was first tested with non radioactive [F-18]fluoride ions and it was shown to repeatedly trap and elute >95% fluoride over 40 successive experimental runs with no decrease in efficiency. The same device was then tested for the trapping and release of [F-18]fluoride ions over 20 experiments with no measurable decrease in performance. Finally, the [F-18]fluoride ions were eluted as a (KF)-F-18/K2.2.2 complex, dried by repeated dissolution in acetonitrile and evaporation of residual water, and reacted with ethyl ditosylate (EtDT) leading to the desired product ([F-18]fluoroethyltosylate) with 96 +/- 3% yield (RCY). The overall time needed for conditioning, trapping, elution and regeneration was less than 6 min. This approach will be of great benefit towards an integrated platform able to perform faster and safer radiochemical synthesis on the micro-scale.

Journal Article Type Article
Publication Date Jul 22, 2011
Journal JOURNAL OF CHROMATOGRAPHY A
Print ISSN 0021-9673
Electronic ISSN 1873-3778
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 1218
Issue 29
Pages 4714-4719
APA6 Citation De Leonardis, F., Pascali, G., Salvadori, P. A., Watts, P., & Pamme, N. (2011). On-chip pre-concentration and complexation of [18F]fluoride ions via regenerable anion exchange particles for radiochemical synthesis of Positron Emission Tomography tracers. Journal of Chromatography A, 1218(29), 4714-4719. https://doi.org/10.1016/j.chroma.2011.05.062
DOI https://doi.org/10.1016/j.chroma.2011.05.062
Keywords Microfiuidics; [F-18]Fluoride; Anion exchange; Positron Emission Tomography (PET)
Publisher URL https://www.sciencedirect.com/science/article/pii/S0021967311007230?via%3Dihub
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