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Effects of exercise prescribed at different levels of claudication pain on walking performance in patients with intermittent claudication: a protocol for a randomised controlled trial

Birkett, Stefan; Sinclair, Jonathan; Seed, Sally; Pymer, Sean; Caldow, Edward; Ingle, Lee; Harwood, Amy; Egun, Anselm

Authors

Stefan Birkett

Jonathan Sinclair

Sally Seed

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Mr Sean Pymer Sean.Pymer@hull.ac.uk
Academic Clinical Exercise Physiologist

Edward Caldow

Amy Harwood

Anselm Egun



Abstract

Background: Peripheral artery disease affects over 236 million people globally and the classic symptom is intermittent claudication (IC) which is associated with reduction in physical activity. The evidence that supervised exercise programmes (SEPs) improve pain-free and maximal walking distance is irrefutable. However, adherence rates are low with exercise-related pain cited as a contributing factor. National and international guidelines recommend exercising at a moderate to maximal level of claudication pain to improve walking ability; however, exercising pain-free or at mild claudication pain has been shown to achieve this outcome. There is limited evidence that compares the relative effects of exercise prescribed at different levels of claudication pain. Objective: The objective of this study is to directly compare the effects of exercise prescribed at three different levels of claudication pain on walking performance. Design: This study will be a single-centre randomised controlled trial. Methods: Based on an a priori power calculation, 51 patients with IC will be allocated to 24 weeks of twice-weekly pain-free (PF), moderate pain (MOD-P) or maximal pain (MAX-P) exercise. The PF group will cease exercise at the onset of claudication (1 on the 0–4 IC rating scale), the MOD-P group will stop once moderate pain is reached (2 on the rating scale) and the MAX-P group will stop once maximal pain is reached (4 on the rating scale). Analysis: Outcome measures will be assessed at baseline, 12 and 24 weeks adopting an analysis of covariance (ANCOVA) to compare MWD across three time points. The primary outcome for the trial will be change in maximal treadmill walking distance at 12 and 24 weeks. Registration: Trial registration number: NCT04370327.

Citation

Birkett, S., Sinclair, J., Seed, S., Pymer, S., Caldow, E., Ingle, L., …Egun, A. (2022). Effects of exercise prescribed at different levels of claudication pain on walking performance in patients with intermittent claudication: a protocol for a randomised controlled trial. Therapeutic Advances in Cardiovascular Disease, 16, https://doi.org/10.1177/17539447221108817

Journal Article Type Article
Acceptance Date Jun 7, 2022
Online Publication Date Jun 28, 2022
Publication Date Jun 28, 2022
Deposit Date Jun 23, 2022
Publicly Available Date Mar 29, 2024
Journal Therapeutic Advances in Cardiovascular Disease
Print ISSN 1753-9447
Electronic ISSN 1753-9455
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 16
DOI https://doi.org/10.1177/17539447221108817
Keywords Pain; Peripheral artery disease; Supervised exercise programme
Public URL https://hull-repository.worktribe.com/output/4018418

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0

Copyright Statement
© The Author(s), 2022.
Creative Commons CC BY: This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).




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