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Putting pressure on elusive polymorphs and solvates

Oswald, Iain D. H.; Chataigner, Isabelle; Elphick, Stephen; Fabbiani, Francesca P. A.; Lennie, Alistair R.; Maddaluno, Jacques; Marshall, William G.; Prior, Timothy J.; Pulham, Colin R.; Smith, Ronald I.

Authors

Iain D. H. Oswald

Isabelle Chataigner

Stephen Elphick

Francesca P. A. Fabbiani

Alistair R. Lennie

Jacques Maddaluno

William G. Marshall

Colin R. Pulham

Ronald I. Smith



Abstract

The reproducible crystallisation of elusive polymorphs and solvates of molecular compounds at high pressure has been demonstrated through studies on maleic acid, malonamide, and paracetamol. These high-pressure methods can be scaled-up to produce 'bulk' quantities of metastable forms that can be recovered to ambient pressure for subsequent seeding experiments. This has been demonstrated for paracetamol form II and paracetamol monohydrate. The studies also show that the particular solid form can be tuned by both pressure and concentration.

Journal Article Type Article
Publication Date Feb 2, 2009
Journal CRYSTENGCOMM
Print ISSN 1466-8033
Electronic ISSN 1466-8033
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 11
Issue 2
Pages 359-366
APA6 Citation Oswald, I. D. H., Chataigner, I., Elphick, S., Fabbiani, F. P. A., Lennie, A. R., Maddaluno, J., …Smith, R. I. (2009). Putting pressure on elusive polymorphs and solvates. CrystEngComm RSC, 11(2), 359-366. https://doi.org/10.1039/b814471k
DOI https://doi.org/10.1039/b814471k
Keywords General Materials Science; General Chemistry; Condensed Matter Physics
Publisher URL https://pubs.rsc.org/en/Content/ArticleLanding/2009/CE/B814471K#!divAbstract
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