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Putting pressure on elusive polymorphs and solvates

Oswald, Iain D. H.; Chataigner, Isabelle; Elphick, Stephen; Fabbiani, Francesca P. A.; Lennie, Alistair R.; Maddaluno, Jacques; Marshall, William G.; Prior, Timothy J.; Pulham, Colin R.; Smith, Ronald I.


Iain D. H. Oswald

Isabelle Chataigner

Stephen Elphick

Francesca P. A. Fabbiani

Alistair R. Lennie

Jacques Maddaluno

William G. Marshall

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Dr Tim Prior
Senior Lecturer in Inorganic Chemistry

Colin R. Pulham

Ronald I. Smith


The reproducible crystallisation of elusive polymorphs and solvates of molecular compounds at high pressure has been demonstrated through studies on maleic acid, malonamide, and paracetamol. These high-pressure methods can be scaled-up to produce 'bulk' quantities of metastable forms that can be recovered to ambient pressure for subsequent seeding experiments. This has been demonstrated for paracetamol form II and paracetamol monohydrate. The studies also show that the particular solid form can be tuned by both pressure and concentration.


Oswald, I. D. H., Chataigner, I., Elphick, S., Fabbiani, F. P. A., Lennie, A. R., Maddaluno, J., …Smith, R. I. (2009). Putting pressure on elusive polymorphs and solvates. CrystEngComm RSC, 11(2), 359-366.

Journal Article Type Article
Acceptance Date Oct 28, 2008
Online Publication Date Nov 28, 2008
Publication Date Feb 2, 2009
Print ISSN 1466-8033
Electronic ISSN 1466-8033
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 11
Issue 2
Pages 359-366
Keywords General Materials Science; General Chemistry; Condensed Matter Physics
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