Putting pressure on elusive polymorphs and solvates

Oswald, Iain D. H.; Chataigner, Isabelle; Elphick, Stephen; Fabbiani, Francesca P. A.; Lennie, Alistair R.; Maddaluno, Jacques; Marshall, William G.; Prior, Timothy J.; Pulham, Colin R.; Smith, Ronald I.

Abstract

The reproducible crystallisation of elusive polymorphs and solvates of molecular compounds at high pressure has been demonstrated through studies on maleic acid, malonamide, and paracetamol. These high-pressure methods can be scaled-up to produce 'bulk' quantities of metastable forms that can be recovered to ambient pressure for subsequent seeding experiments. This has been demonstrated for paracetamol form II and paracetamol monohydrate. The studies also show that the particular solid form can be tuned by both pressure and concentration.

Citation

Oswald, I. D. H., Chataigner, I., Elphick, S., Fabbiani, F. P. A., Lennie, A. R., Maddaluno, J., Marshall, W. G., Prior, T. J., Pulham, C. R., & Smith, R. I. (2009). Putting pressure on elusive polymorphs and solvates. CrystEngComm RSC, 11(2), 359-366. https://doi.org/10.1039/b814471k

• Journal Article Type: Article
• Acceptance Date: Oct 28, 2008
• Online Publication Date: Nov 28, 2008
• Publication Date: Feb 2, 2009
• Journal: CRYSTENGCOMM
• Print ISSN: 1466-8033
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 2
• Pages: 359-366
• DOI: https://doi.org/10.1039/b814471k
• Keywords: General Materials Science; General Chemistry; Condensed Matter Physics
• Public URL: https://hull-repository.worktribe.com/output/405216
• Publisher URL: https://pubs.rsc.org/en/Content/ArticleLanding/2009/CE/B814471K#!divAbstract