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Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus

Sadeghi, Mahvash; Dehnavi, Sajad; Shohan, Mojtaba; Jamialahmadi, Tannaz; Sathyapalan, Thozhukat; Sahebkar, Amirhossein


Mahvash Sadeghi

Sajad Dehnavi

Mojtaba Shohan

Tannaz Jamialahmadi

Amirhossein Sahebkar


Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and associated with multiple organ systems complications. The incidence and prevalence of diabetes are increasing in an epidemic proportion worldwide. In addition to environmental factors, some epigenetic and post-translational modifications have critical roles in the pathogenesis of diabetes and its complications. Reversible covalent modification such as SUMOylation by SUMO (Small Ubiquitin-like Modifier) has emerged as a new mechanism that affects the dynamic regulation of proteins. In this review, we initially focus on the function of SUMO and SUMOylation. Subsequently, we assess the potential effects of this process in the pathogenesis of type 1 and 2 diabetes mellitus.


Sadeghi, M., Dehnavi, S., Shohan, M., Jamialahmadi, T., Sathyapalan, T., & Sahebkar, A. (2023). Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus. Current medicinal chemistry, 30(14), 1623-1637.

Journal Article Type Article
Acceptance Date Aug 2, 2022
Online Publication Date Sep 23, 2022
Publication Date Apr 1, 2023
Deposit Date Aug 28, 2022
Publicly Available Date Sep 24, 2023
Journal Current Medicinal Chemistry
Print ISSN 0929-8673
Electronic ISSN 1875-533X
Publisher Bentham Science Publishers
Peer Reviewed Peer Reviewed
Volume 30
Issue 14
Pages 1623-1637
Keywords Pharmacology; Molecular Medicine; Drug Discovery; Biochemistry; Organic Chemistry
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