Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus

Sadeghi, Mahvash; Dehnavi, Sajad; Shohan, Mojtaba; Jamialahmadi, Tannaz; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Abstract

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and associated with multiple organ systems complications. The incidence and prevalence of diabetes are increasing in an epidemic proportion worldwide. In addition to environmental factors, some epigenetic and post-translational modifications have critical roles in the pathogenesis of diabetes and its complications. Reversible covalent modification such as SUMOylation by SUMO (Small Ubiquitin-like Modifier) has emerged as a new mechanism that affects the dynamic regulation of proteins. In this review, we initially focus on the function of SUMO and SUMOylation. Subsequently, we assess the potential effects of this process in the pathogenesis of type 1 and 2 diabetes mellitus.

Citation

Sadeghi, M., Dehnavi, S., Shohan, M., Jamialahmadi, T., Sathyapalan, T., & Sahebkar, A. (2023). Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus. Current medicinal chemistry, 30(14), 1623-1637. https://doi.org/10.2174/0929867329666220817142848

• Journal Article Type: Article
• Acceptance Date: Aug 2, 2022
• Online Publication Date: Sep 23, 2022
• Publication Date: Apr 1, 2023
• Deposit Date: Aug 28, 2022
• Publicly Available Date: Sep 24, 2023
• Journal: Current Medicinal Chemistry
• Print ISSN: 0929-8673
• Publisher: Bentham Science Publishers
• Peer Reviewed: Peer Reviewed
• Volume: 30
• Issue: 14
• Pages: 1623-1637
• DOI: https://doi.org/10.2174/0929867329666220817142848
• Keywords: Pharmacology; Molecular Medicine; Drug Discovery; Biochemistry; Organic Chemistry
• Public URL: https://hull-repository.worktribe.com/output/4062847