Supramolecular Room-Temperature Phosphorescent Hydrogel Based on Hexamethyl Cucurbit[5]uril for Cell Imaging

Sun, Xi Ran; Yang, Hai Ping; Zhang, Wei; Zhang, Shuai; Hu, Jian Hang; Liu, Ming; Zeng, Xi; Li, Qiu; Redshaw, Carl; Tao, Zhu; Xiao, Xin

Abstract

The host-guest interaction between hexamethyl cucurbit[5]uril (HmeQ[5]) and 1,4-diaminobenzene (DB) was investigated, and a new low-molecular-weight supramolecular gel was prepared by a simple heating/mixing cooling method. The structure and properties of the supramolecular gel were characterized. Results revealed that DB molecules did not enter the cavity of HmeQ[5] and that hydrogen bonding between the carbonyl group at the HmeQ[5] port and the DB amino groups, together with dipole-dipole interactions and outer wall interactions, were the main driving forces for the formation of the supramolecular gel. The HmeQ[5]/DB gel system exhibits temperature sensitivity. The phosphor 6-bromo-2-naphthol (BrNp) was embedded in the gel to give the gel fluorescent phosphorescence double emission. The double emission ability at room temperature can be attributed to the ordered microstructure of the supramolecular gel, which effectively avoids the nonradiative transition of BrNp. Meanwhile, HmeQ[5]/DB-BrNp has good biocompatibility and low biotoxicity, which is compatible with HeLa cells to achieve cytoplasmic staining of HeLa in the red channel. The supramolecular gels constructed by this supramolecular assembly strategy not only have good temperature sensitivity but also extend the application of Q[n]s in biomedical fields.

Citation

Sun, X. R., Yang, H. P., Zhang, W., Zhang, S., Hu, J. H., Liu, M., Zeng, X., Li, Q., Redshaw, C., Tao, Z., & Xiao, X. (2023). Supramolecular Room-Temperature Phosphorescent Hydrogel Based on Hexamethyl Cucurbit[5]uril for Cell Imaging. ACS Applied Materials & Interfaces, https://doi.org/10.1021/acsami.2c17891

• Journal Article Type: Article
• Acceptance Date: Jan 4, 2023
• Online Publication Date: Jan 14, 2023
• Publication Date: Jan 25, 2023
• Deposit Date: Jan 17, 2023
• Publicly Available Date: Jan 15, 2024
• Journal: ACS Applied Materials and Interfaces
• Print ISSN: 1944-8244
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1021/acsami.2c17891
• Keywords: General Materials Science
• Public URL: https://hull-repository.worktribe.com/output/4183835