Skip to main content

Research Repository

Advanced Search

Thermoresponsive and reducible hyperbranched polymers synthesized by RAFT polymerisation

Tochwin, Anna; El-Betany, Alaa; Tai, Hongyun; Chan, Kai Yu; Blackburn, Chester; Wang, Wenxin


Anna Tochwin

Profile Image

Dr Alaa Elbetany
Lecturer in Organic and Materials Chemistry

Hongyun Tai

Kai Yu Chan

Chester Blackburn

Wenxin Wang


Here, we report the synthesis of new thermoresponsive hyperbranched polymers (HBPs) via one-pot reversible addition-fragmentation chain transfer (RAFT) copolymerisation of poly(ethylene glycol)methyl ether methacrylate (PEGMEMA,Mn = 475 g/mol), poly(propylene glycol)methacrylate (PPGMA,Mn = 375 g/mol), and disulfide diacrylate (DSDA) using 2-cyanoprop-2-yl dithiobenzoate as a RAFT agent. DSDA was used as the branching agent and to afford the HBPs with reducible disulfide groups. The resulting HBPs were characterised by Nuclear Magnetic Resonance Spectroscopy (NMR) and Gel Permeation Chromatography (GPC). Differential Scanning Calorimetry (DSC) was used to determine lower critical solution temperatures (LCSTs) of these copolymers, which are in the range of 17-57 °C. Moreover, the studies on the reducibility of HBPs and swelling behaviours of hydrogels synthesized from these HBPs were conducted. The results demonstrated that we have successfully synthesized hyperbranched polymers with desired dual responsive (thermal and reducible) and crosslinkable (via thiol-ene click chemistry) properties. In addition, these new HBPs carry the multiplicity of reactive functionalities, such as RAFT agent moieties and multivinyl functional groups, which can afford them with the capacity for further bioconjugation and structure modifications.


Tochwin, A., El-Betany, A., Tai, H., Chan, K. Y., Blackburn, C., & Wang, W. (2017). Thermoresponsive and reducible hyperbranched polymers synthesized by RAFT polymerisation. Polymers, 9(9), Article 443.

Journal Article Type Article
Acceptance Date Sep 6, 2017
Online Publication Date Sep 13, 2017
Publication Date 2017-09
Deposit Date Feb 25, 2023
Publicly Available Date Mar 2, 2023
Journal Polymers
Electronic ISSN 2073-4360
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 9
Issue 9
Article Number 443
Keywords Hyperbranched polymers; Thermoresponsive; Reducible; RAFT polymerisation; Disulfide diacrylate; Hydrogels
Public URL


You might also like

Downloadable Citations