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Supramolecular Assembly of Tetramethylcucurbit[6]uril and 2-Picolylamine

Fan, Ying; Cen, Ran; Shan, Peihui; Redshaw, Carl; Cong, Hang; Xiao, Xin; Ge, Qingmei


Ying Fan

Ran Cen

Peihui Shan

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Professor Carl Redshaw
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry

Hang Cong

Xin Xiao

Qingmei Ge


The supramolecular assembly of symmetrical tetramethylcucurbit[6]uril (TMeQ[6]) and 2-picolylamine (AMPy) has been investigated via various techniques, including ultraviolet-visible (UV-vis) and nuclear magnetic resonance spectroscopy, isothermal titration calorimetry (ITC), and X-ray crystallography. The results indicated that TMeQ[6] could encapsulate the AMPy guest molecule to form a stable inclusion complex. The rotational restriction of the guest in the cavity of TMeQ[6] resulted in a large negative value of entropy. The X-ray crystal structure of the 1:1 inclusion complex between TMeQ[6] and AMPy revealed that AMPy exists in the elliptical cavity of TMeQ[6].


Fan, Y., Cen, R., Shan, P., Redshaw, C., Cong, H., Xiao, X., & Ge, Q. (2023). Supramolecular Assembly of Tetramethylcucurbit[6]uril and 2-Picolylamine. ACS Omega, 8(11), 9919–9924.

Journal Article Type Article
Acceptance Date Feb 23, 2023
Online Publication Date Mar 6, 2023
Publication Date Mar 21, 2023
Deposit Date Mar 8, 2023
Publicly Available Date Mar 24, 2023
Journal ACS Omega
Print ISSN 2470-1343
Electronic ISSN 2470-1343
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 8
Issue 11
Pages 9919–9924
Keywords General Chemical Engineering; General Chemistry
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© 2023 The Authors. Published by American Chemical Society.<br /> Creative Commons Licence: Attribution-NonCommercial-NoDerivatives 4.0 International License. See:

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