Microfluidic platforms for performing surface-based clinical assays

Tarn, Mark D.; Pamme, Nicole

Abstract

The need for fast, specific and portable diagnostic systems for clinical assays has, in recent years, led to an explosion of research into microfluidic chip-based immunoassays towards rapid point-of-care analysis. Such devices exploit small dimensions, superior fluidic control and low reagent volumes to allow a number of clinically important procedures to be achieved with improvements on conventional methods, many of which rely on the surface-based binding of antigens to antibodies. Here, we discuss recent developments and innovations in the area of on-chip surface-based immunoassays and provide an outlook on the potential of such platforms for future diagnostics.

Citation

Tarn, M. D., & Pamme, N. (2011). Microfluidic platforms for performing surface-based clinical assays. Expert review of molecular diagnostics, 11(7), 711-720. https://doi.org/10.1586/ERM.11.59

• Journal Article Type: Article
• Online Publication Date: Jan 9, 2014
• Publication Date: 2011-09
• Journal: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
• Print ISSN: 1473-7159
• Publisher: Taylor and Francis
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 7
• Pages: 711-720
• DOI: https://doi.org/10.1586/ERM.11.59
• Keywords: Clinical assays; Diagnostics; Heterogeneous immunoassays; Magnetic particles; Microfluidics; Particles; Surface-based
• Public URL: https://hull-repository.worktribe.com/output/424115
• Publisher URL: https://www.tandfonline.com/doi/full/10.1586/erm.11.59