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Factor VII deficiency: a cause of (or risk factor for) bleeding?

Hampshire, Daniel J.



Among the rare bleeding disorders factor VII deficiency is the most common, but correlating deficiency with bleeding phenotype is challenging. In their study Lou and colleagues investigate a large cohort of unrelated factor VII deficient patients providing a further perspective on the link between genotype and phenotype in this disorder. Commentary on: Lou et al. Structural and functional characterization of novel F7 mutations identified in Chinese factor VII deficient patients. Br J Haematol. 2023 (Online ahead of print). doi: 10.1111/bjh.18768.


Hampshire, D. J. (2023). Factor VII deficiency: a cause of (or risk factor for) bleeding?. British journal of haematology, 202(3), 457-458.

Journal Article Type Commentary
Acceptance Date Mar 30, 2023
Online Publication Date Apr 12, 2023
Publication Date Aug 1, 2023
Deposit Date Jun 16, 2023
Publicly Available Date Apr 13, 2024
Journal British Journal of Haematology
Print ISSN 0007-1048
Electronic ISSN 1365-2141
Publisher Wiley
Peer Reviewed Not Peer Reviewed
Volume 202
Issue 3
Pages 457-458
Keywords Bleeding; Factor VII deficiency; Genotype–phenotype correlation
Public URL


Accepted manuscript (369 Kb)

Copyright Statement
This is the peer reviewed version of the following article: Hampshire, DJ. Factor VII deficiency: A cause of (or risk factor for) bleeding? Br J Haematol. 2023; 00: 1– 2., which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

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