Dr Dan Hampshire
| Biography | Post-PhD, I worked within the Haemostasis Research Group (University of Sheffield) with Prof. Anne Goodeve and Prof. Ian Peake for 12 years funded by a USA National Institutes of Health Program Project Grant (NIH-PPG) in collaboration with colleagues based at the BloodCenter of Wisconsin, Milwaukee WI, USA (Prof. Robert Montgomery) and Queen’s University, Kingston ON, Canada (Prof. David Lillicrap). My initial research associated with this NIH-PPG as a postdoctoral researcher revealed a range of genetic mechanisms involved in the pathogenesis of the bleeding disorder von Willebrand disease that result in quantitative deficiency or functional defects of the plasma glycoprotein von Willebrand factor (VWF). My role in this NIH-PPG subsequently developed into a Senior Scientist as I began to design and supervise (in addition to conduct) my own research focused specifically on identifying genetic factors that may contribute to the unusually wide variation in VWF plasma levels observed in the general population. |
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| Research Interests | My research focuses specifically on identifying genetic factors that may contribute to the unusually wide variation in von Willebrand factor (VWF) plasma levels observed in the general population. An increased understanding of the factors influencing VWF levels has important implications given that variation in VWF levels is associated with susceptibility to both bleeding (reduced VWF levels) and thrombosis (elevated levels). My research in this area has investigated the transcriptional regulation of the VWF gene and other genetic modifiers of VWF level including single nucleotide variants within the VWF locus previously thought to be ‘neutral’ common polymorphisms. Applying the knowledge and experience I have gained to date, I now aim to ascertain the role that natural variation in plasma VWF levels has in determining clinical outcomes following treatment in patients with acute coronary syndromes. |
| Teaching and Learning | I am the Programme Director for the MSc in Biomedical Sciences, where I teach on the modules Diseases in Biomedicine and Biomedical Sciences Research Project (module lead). As part of the BSc in Biomedical Science degree programme, I currently teach on the following modules: Blood Sciences (level 5), Clinical Haematology (level 6) and Human Genetics (level 6). I also deliver material for MBBS Phase I. I supervise both undergraduate and taught postgraduate research projects. |
| Scopus Author ID | 7005183416 |