Skip to main content

Research Repository

Advanced Search

Exercise and postprandial lipaemia: effects on peripheral vascular function, oxidative stress and gastrointestinal transit

Clegg, Miriam; McClean, Conor; Davison, W. Gareth; Murphy, H. Marie; Trinick, Tom; Duly, Ellie; McLaughlin, Jim; Fogarty, Mark; Shafat, Amir

Authors

Miriam Clegg

Conor McClean

W. Gareth Davison

H. Marie Murphy

Tom Trinick

Ellie Duly

Jim McLaughlin

Mark Fogarty M.Fogarty@hull.ac.uk

Amir Shafat



Abstract

Postprandial lipaemia may lead to an increase in oxidative stress, inducing endothelial dysfunction. Exercise can slow gastric emptying rates, moderating postprandial lipaemia. The purpose of this study was to determine if moderate exercise, prior to fat ingestion, influences gastrointestinal transit, lipaemia, oxidative stress and arterial wall function. Eight apparently healthy males (age 23.6 ± 2.8 yrs; height 181.4 ± 8.1 cm; weight 83.4 ± 16.2 kg; all data mean ± SD) participated in the randomised, crossover design, where (i) subjects ingested a high-fat meal alone (control), and (ii) ingested a high-fat meal, preceded by 1 h of moderate exercise. Pulse Wave Velocity (PWV) was examined at baseline, post-exercise, and in the postprandial period. Gastric emptying was measured using the 13C-octanoic acid breath test. Measures of venous blood were obtained prior to and following exercise and at 2, 4 and 6 hours post-ingestion. PWV increased (6.5 ± 1.9 m/sec) at 2 (8.9 ± 1.7 m/sec) and 4 hrs (9.0 ± 1.6 m/sec) post-ingestion in the control group (time × group interaction, P < 0.05). PWV was increased at 2 hrs post-ingestion in the control compared to the exercise trial; 8.9 ± 1.7 vs. 6.2 ± 1.5 m/sec (time × group interaction, P < 0.05). Lipid hydroperoxides increased over time (pooled exercise and control data, P < 0.05). Serum triacylglycerols were elevated postprandially (pooled exercise and control data, P < 0.05). There were no changes in gastric emptying, cholesterol, or C-reactive protein levels. These data suggest that acute exercise prior to the consumption of a high-fat meal has the potential to reduce vascular impairments.

Citation

Clegg, M., McClean, C., Davison, W. G., Murphy, H. M., Trinick, T., Duly, E., …Shafat, A. (2007). Exercise and postprandial lipaemia: effects on peripheral vascular function, oxidative stress and gastrointestinal transit. Lipids in Health and Disease, 6(1), doi:10.1186/1476-511X-6-30. ISSN 1476-511X

Journal Article Type Article
Acceptance Date Oct 31, 2007
Online Publication Date Oct 31, 2007
Publication Date 2007
Journal Lipids in Health and Disease
Print ISSN 1476-511X
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 6
Issue 1
Article Number 30
DOI https://doi.org/10.1186/1476-511X-6-30
Keywords Pulse wave velocity; Gastrointestinal transit; Postprandial lipaemia; Exercise trial; Moderate intensity exercise
Public URL https://hull-repository.worktribe.com/output/428957
Publisher URL https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-6-30
Copyright Statement © 2007 Clegg et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Files

Article (240 Kb)
PDF

Publisher Licence URL
http://creativecommons.org/licenses/by/2.0

Copyright Statement
© 2007 Clegg et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.





You might also like



Downloadable Citations