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Biomarkers of coronary endothelial health: correlation with invasive measures of collateral function, flow and resistance in chronically occluded coronary arteries and the effect of recanalization

Ladwiniec, Andrew; Ettelaie, Camille; Cunnington, Michael S.; Rossington, Jennifer; Thackray, Simon; Alamgir, Farquad; Hoye, Angela

Authors

Andrew Ladwiniec

Camille Ettelaie

Michael S. Cunnington

Jennifer Rossington

Simon Thackray

Farquad Alamgir

Angela Hoye

Abstract

Objectives: In the presence of a chronically occluded coronary artery, the collateral circulation matures by a process of arteriogenesis; however, there is considerable variation between individuals in the functional capacity of that collateral network. This could be explained by differences in endothelial health and function. We aimed to examine the relationship between the functional extent of collateralization and levels of biomarkers that have been shown to relate to endothelial health. Methods: We measured four potential biomarkers of endothelial health in 34 patients with mature collateral networks who underwent a successful percutaneous coronary intervention (PCI) for a chronic total coronary occlusion (CTO) before PCI and 6-8 weeks after PCI, and examined the relationship of biomarker levels with physiological measures of collateralization. Results: We did not find a significant change in the systemic levels of sICAM-1, sE-selectin, microparticles or tissue factor 6-8 weeks after PCI. We did find an association between estimated retrograde collateral flow before CTO recanalization and lower levels of sICAM-1 (r=0.39, P=0.026), sE-selectin (r=0.48, P=0.005) and microparticles (r=0.38, P=0.03). Conclusion: Recanalization of a CTO and resultant regression of a mature collateral circulation do not alter systemic levels of sICAM-1, sE-selectin, microparticles or tissue factor. The identified relationship of retrograde collateral flow with sICAM-1, sE-selectin and microparticles is likely to represent an association with an ability to develop collaterals rather than their presence and extent.

Publication Date 2016-06
Journal Coronary artery disease
Print ISSN 0954-6928
Electronic ISSN 1473-5830
Publisher Lippincott, Williams & Wilkins
Peer Reviewed Peer Reviewed
Volume 27
Issue 4
Pages 287-294
Institution Citation Ladwiniec, A., Ettelaie, C., Cunnington, M. S., Rossington, J., Thackray, S., Alamgir, F., & Hoye, A. (2016). Biomarkers of coronary endothelial health: correlation with invasive measures of collateral function, flow and resistance in chronically occluded coronary arteries and the effect of recanalization. Coronary Artery Disease, 27(4), 287-294. https://doi.org/10.1097/mca.0000000000000360
DOI https://doi.org/10.1097/mca.0000000000000360
Keywords Biomarkers, Chronic total coronary occlusion, Collateral circulation, Percutaneous coronary intervention.
Publisher URL http://journals.lww.com/coronary-artery/Abstract/2016/06000/Biomarkers_of_coronary_endothelial_health__.7.aspx
Copyright Statement © 2017 The Authors.
Additional Information This is a description of an article which has been published in: Coronary artery disease, 2016, v.27, issue 4

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