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Biological optimisation, the Goldilocks principle, and how much is lagom in the preimplantation embryo

Guerif, Fabrice; Leese, Henry J.; Guérif, Fabrice; Allgar, Victoria; Brison, Daniel R.; Lundin, Kersti; Sturmey, Roger G.

Authors

Fabrice Guerif

Henry J. Leese

Fabrice Guérif

Victoria Allgar

Daniel R. Brison

Kersti Lundin



Abstract

The quiet embryo hypothesis postulates that early embryo viability is associated with a relatively low metabolism (Leese. 2002. BioEssays 24: 845-849). This proposal is re-visited here using retrospective and prospective data on the metabolic activity and kinetics of preimplantation development alongside the concept that an optimal range of such indices and of energetic efficiency influences embryogenesis. It is concluded that these considerations may be rationalised by proposing the existence of a ‘Goldilocks zone’, or as it is known in Sweden, of lagom –meaning “just the right amount”– within which embryos with maximum developmental potential can be categorised.

Citation

Leese, H. J., Guérif, F., Allgar, V., Brison, D. R., Lundin, K., & Sturmey, R. G. (2016). Biological optimisation, the Goldilocks principle, and how much is lagom in the preimplantation embryo. Molecular Reproduction and Development, 83(9), 748-754. https://doi.org/10.1002/mrd.22684

Acceptance Date Jul 18, 2016
Online Publication Date Oct 12, 2016
Publication Date Jul 28, 2016
Deposit Date Jul 22, 2016
Publicly Available Date Jul 28, 2016
Journal Molecular reproduction and development
Print ISSN 1040-452X
Electronic ISSN 1098-2795
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 83
Issue 9
Pages 748-754
DOI https://doi.org/10.1002/mrd.22684
Keywords Biological optimization, Metabolism, Nutrition, Preimplantation
Public URL https://hull-repository.worktribe.com/output/441517
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/mrd.22684/full
Copyright Statement ©2017 University of Hull

Authors' accepted manuscript of article: Leese, H. J., Guerif, F., Allgar, V., Brison, D. R., Lundin, K. and Sturmey, R. G. (2016), Biological optimization, the Goldilocks principle, and how much is lagom in the preimplantation embryo. Mol. Reprod. Dev., 83: 748–754. doi:10.1002/mrd.22684
Additional Information Authors' accepted manuscript of article: Leese, H. J., Guerif, F., Allgar, V., Brison, D. R., Lundin, K. and Sturmey, R. G. (2016), Biological optimization, the Goldilocks principle, and how much is lagom in the preimplantation embryo. Mol. Reprod. Dev., 83: 748–754. doi:10.1002/mrd.22684

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Copyright Statement
©2017 University of Hull

Authors' accepted manuscript of article: Leese, H. J., Guerif, F., Allgar, V., Brison, D. R., Lundin, K. and Sturmey, R. G. (2016), Biological optimization, the Goldilocks principle, and how much is lagom in the preimplantation embryo. Mol. Reprod. Dev., 83: 748–754. doi:10.1002/mrd.22684





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