Biological optimisation, the Goldilocks principle, and how much is lagom in the preimplantation embryo

Leese, Henry J.; Gue?rif, Fabrice; Allgar, Victoria; Brison, Daniel R.; Lundin, Kersti; Sturmey, Roger G.

Abstract

The quiet embryo hypothesis postulates that early embryo viability is associated with a relatively low metabolism (Leese. 2002. BioEssays 24: 845-849). This proposal is re-visited here using retrospective and prospective data on the metabolic activity and kinetics of preimplantation development alongside the concept that an optimal range of such indices and of energetic efficiency influences embryogenesis. It is concluded that these considerations may be rationalised by proposing the existence of a ‘Goldilocks zone’, or as it is known in Sweden, of lagom –meaning “just the right amount”– within which embryos with maximum developmental potential can be categorised.

Citation

Leese, H. J., Guérif, F., Allgar, V., Brison, D. R., Lundin, K., & Sturmey, R. G. (2016). Biological optimisation, the Goldilocks principle, and how much is lagom in the preimplantation embryo. Molecular Reproduction and Development, 83(9), 748-754. https://doi.org/10.1002/mrd.22684

• Acceptance Date: Jul 18, 2016
• Online Publication Date: Oct 12, 2016
• Publication Date: Jul 28, 2016
• Deposit Date: Jul 22, 2016
• Publicly Available Date: Jul 28, 2016
• Journal: Molecular reproduction and development
• Print ISSN: 1040-452X
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 83
• Issue: 9
• Pages: 748-754
• DOI: https://doi.org/10.1002/mrd.22684
• Keywords: Biological optimization, Metabolism, Nutrition, Preimplantation
• Public URL: https://hull-repository.worktribe.com/output/441517
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1002/mrd.22684/full
• Additional Information: Authors' accepted manuscript of article: Leese, H. J., Guerif, F., Allgar, V., Brison, D. R., Lundin, K. and Sturmey, R. G. (2016), Biological optimization, the Goldilocks principle, and how much is lagom in the preimplantation embryo. Mol. Reprod. Dev., 83: 748–754. doi:10.1002/mrd.22684
• Contract Date: Jul 22, 2016