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Stabilisation of metastable polymorphs: the case of paracetamol form III

Telford, Richard; Seaton, Colin C.; Clout, Alexander; Buanz, Asma; Gaisford, Simon; Williams, Gareth R.; Prior, Timothy J.; Okoye, Chidera H.; Munshi, Tasnim; Scowen, Ian J.

Authors

Richard Telford

Colin C. Seaton

Alexander Clout

Asma Buanz

Simon Gaisford

Gareth R. Williams

Chidera H. Okoye

Tasnim Munshi

Ian J. Scowen



Abstract

The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermospectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of b-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph.

Citation

Telford, R., Seaton, C. C., Clout, A., Buanz, A., Gaisford, S., Williams, G. R., …Scowen, I. J. (2016). Stabilisation of metastable polymorphs: the case of paracetamol form III. Chemical communications : Chem comm / the Royal Society of Chemistry, 52(81), 12028-12031. https://doi.org/10.1039/c6cc05006a

Journal Article Type Article
Acceptance Date Aug 5, 2016
Online Publication Date Aug 5, 2016
Publication Date Aug 5, 2016
Deposit Date Aug 15, 2016
Publicly Available Date Aug 15, 2016
Journal Chemical communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 52
Issue 81
Pages 12028-12031
DOI https://doi.org/10.1039/c6cc05006a
Keywords Materials Chemistry; Electronic, Optical and Magnetic Materials; General Chemistry; Surfaces, Coatings and Films; Metals and Alloys; Ceramics and Composites; Catalysis
Public URL https://hull-repository.worktribe.com/output/442212
Publisher URL http://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc05006a#!divAbstract
Copyright Statement This Open Access Article is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported Licence
Additional Information Copy of article first published in: Chemical communications, 2016, v.52 issue 81.

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Copyright Statement
This Open Access Article is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported Licence



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