Stabilisation of metastable polymorphs: the case of paracetamol form III

Telford, Richard; Seaton, Colin C.; Clout, Alexander; Buanz, Asma; Gaisford, Simon; Williams, Gareth R.; Prior, Timothy J.; Okoye, Chidera H.; Munshi, Tasnim; Scowen, Ian J.

Abstract

The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermospectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of b-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph.

Citation

Telford, R., Seaton, C. C., Clout, A., Buanz, A., Gaisford, S., Williams, G. R., Prior, T. J., Okoye, C. H., Munshi, T., & Scowen, I. J. (2016). Stabilisation of metastable polymorphs: the case of paracetamol form III. Chemical communications : Chem comm / the Royal Society of Chemistry, 52(81), 12028-12031. https://doi.org/10.1039/c6cc05006a

• Journal Article Type: Article
• Acceptance Date: Aug 5, 2016
• Online Publication Date: Aug 5, 2016
• Publication Date: Aug 5, 2016
• Deposit Date: Aug 15, 2016
• Publicly Available Date: Aug 15, 2016
• Journal: Chemical communications
• Print ISSN: 1359-7345
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 52
• Issue: 81
• Pages: 12028-12031
• DOI: https://doi.org/10.1039/c6cc05006a
• Keywords: Materials Chemistry; Electronic, Optical and Magnetic Materials; General Chemistry; Surfaces, Coatings and Films; Metals and Alloys; Ceramics and Composites; Catalysis
• Public URL: https://hull-repository.worktribe.com/output/442212
• Publisher URL: http://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc05006a#!divAbstract
• Additional Information: Copy of article first published in: Chemical communications, 2016, v.52 issue 81.
• Contract Date: Aug 15, 2016