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A disposable microfluidic device with a screen printed electrode for mimicking phase II metabolism

Vasiliadou, Rafaela; Esfahani, Mohammad Mehdi Nasr; Brown, Nathan J.; Welham, Kevin J.


Rafaela Vasiliadou

Mohammad Mehdi Nasr Esfahani

Nathan J. Brown

Kevin J. Welham


Human metabolism is investigated using several in vitro methods. However, the current methodologies are often expensive, tedious and complicated. Over the last decade, the combination of electrochemistry (EC) with mass spectrometry (MS) has a simpler and a cheaper alternative to mimic the human metabolism. This paper describes the development of a disposable microfluidic device with a screen-printed electrode (SPE) for monitoring phase II GSH reactions. The proposed chip has the potential to be used as a primary screening tool, thus complementing the current in vitro methods.


Vasiliadou, R., Esfahani, M. M. N., Brown, N. J., & Welham, K. J. (2016). A disposable microfluidic device with a screen printed electrode for mimicking phase II metabolism. Sensors, 16(9), Article ARTN 1418.

Journal Article Type Article
Acceptance Date Aug 25, 2016
Online Publication Date Sep 2, 2016
Publication Date Sep 2, 2016
Deposit Date Sep 14, 2016
Publicly Available Date Sep 14, 2016
Journal Sensors
Electronic ISSN 1424-8220
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 16
Issue 9
Article Number ARTN 1418
Keywords Metabolism, Electrochemistry, Screen-printed electrodes, Mass spectrometry
Public URL
Publisher URL
Additional Information Copy of article first published in: Sensors, 2016, v.16, issue 9.


Published article (4.2 Mb)

Copyright Statement
This is an open access article distributed under the Creative Commons Attribution License (CC BY 4.0).

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