A disposable microfluidic device with a screen printed electrode for mimicking phase II metabolism

Nasr Esfahani, Mohammad; Brown, Nathan; Brown, Nathan J.; Welham, Kevin J.; Vasiliadou, Rafaela; Esfahani, Mohammad Mehdi Nasr; Brown, Nathan J.; Welham, Kevin J.

Abstract

Human metabolism is investigated using several in vitro methods. However, the current methodologies are often expensive, tedious and complicated. Over the last decade, the combination of electrochemistry (EC) with mass spectrometry (MS) has a simpler and a cheaper alternative to mimic the human metabolism. This paper describes the development of a disposable microfluidic device with a screen-printed electrode (SPE) for monitoring phase II GSH reactions. The proposed chip has the potential to be used as a primary screening tool, thus complementing the current in vitro methods.

• Journal Article Type: Article
• Publication Date: Sep 2, 2016
• Journal: Sensors
• Print ISSN: 1424-8220
• Electronic ISSN: 1424-8220
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 16
• Issue: 9
• Article Number: ARTN 1418
• APA6 Citation: Vasiliadou, R., Esfahani, M. M. N., Brown, N. J., & Welham, K. J. (2016). A disposable microfluidic device with a screen printed electrode for mimicking phase II metabolism. Sensors, 16(9), doi:10.3390/s16091418
• DOI: https://doi.org/10.3390/s16091418
• Keywords: Metabolism, Electrochemistry, Screen-printed electrodes, Mass spectrometry
• Publisher URL: http://www.mdpi.com/1424-8220/16/9/1418
• Copyright Statement: This is an open access article distributed under the Creative Commons Attribution License (CC BY 4.0).
• Additional Information: Copy of article first published in: Sensors, 2016, v.16, issue 9.