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A disposable microfluidic device with a screen printed electrode for mimicking phase II metabolism

Nasr Esfahani, Mohammad; Brown, Nathan; Brown, Nathan J.; Welham, Kevin J.; Vasiliadou, Rafaela; Esfahani, Mohammad Mehdi Nasr; Brown, Nathan J.; Welham, Kevin J.

Authors

Mohammad Nasr Esfahani

Nathan Brown

Nathan J. Brown

Kevin J. Welham

Rafaela Vasiliadou

Mohammad Mehdi Nasr Esfahani

Kevin J. Welham



Abstract

Human metabolism is investigated using several in vitro methods. However, the current methodologies are often expensive, tedious and complicated. Over the last decade, the combination of electrochemistry (EC) with mass spectrometry (MS) has a simpler and a cheaper alternative to mimic the human metabolism. This paper describes the development of a disposable microfluidic device with a screen-printed electrode (SPE) for monitoring phase II GSH reactions. The proposed chip has the potential to be used as a primary screening tool, thus complementing the current in vitro methods.

Journal Article Type Article
Publication Date Sep 2, 2016
Journal Sensors
Print ISSN 1424-8220
Electronic ISSN 1424-8220
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 16
Issue 9
Article Number ARTN 1418
APA6 Citation Vasiliadou, R., Esfahani, M. M. N., Brown, N. J., & Welham, K. J. (2016). A disposable microfluidic device with a screen printed electrode for mimicking phase II metabolism. Sensors, 16(9), doi:10.3390/s16091418
DOI https://doi.org/10.3390/s16091418
Keywords Metabolism, Electrochemistry, Screen-printed electrodes, Mass spectrometry
Publisher URL http://www.mdpi.com/1424-8220/16/9/1418
Copyright Statement This is an open access article distributed under the Creative Commons Attribution License (CC BY 4.0).
Additional Information Copy of article first published in: Sensors, 2016, v.16, issue 9.

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Copyright Statement
This is an open access article distributed under the Creative Commons Attribution License (CC BY 4.0).





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